Metabolism Antibodies 1
Anti-PLA2G2A Antibody (CAB1234)
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- SKU:
- CAB1234
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-PLA2G2A Antibody |
| Antibody SKU: | CAB1234 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-144 of human PLA2G2A (NP_001155201.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | BT-474, Mouse intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-144 of human PLA2G2A (NP_001155201.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NLVN FHRM IKLT TGKE AALS YGFY GCHC GVGG RGSP KDAT DRCC VTHD CCYK RLEK RGCG TKFL SYKF SNSG SRIT CAKQ DSCR SQLC ECDK AAAT CFAR NKTT YNKK YQYY SNKH CRGS TPRC |
| Gene ID: | 5320 |
| Uniprot: | P14555 |
| Cellular Location: | Membrane, Peripheral membrane protein |
| Calculated MW: | 16kDa |
| Observed MW: | 18kDa |
| Synonyms: | PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2 |
| Background: | The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene. |
| UniProt Protein Function: | PLA2G2A: Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Belongs to the phospholipase A2 family. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - arachidonic acid; Secreted, signal peptide; Vesicle; Endoplasmic reticulum; Phospholipase; EC 3.1.1.4; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Lipid Metabolism - alpha-linolenic acid; Mitochondrial; Secreted; Lipid Metabolism - linoleic acid Chromosomal Location of Human Ortholog: 1p35 Cellular Component: extracellular space; endoplasmic reticulum membrane; mitochondrion; endoplasmic reticulum; extracellular region; secretory granule Molecular Function:phospholipase A2 activity; calcium-dependent phospholipase A2 activity; phospholipid binding; calcium ion binding Biological Process: defense response to Gram-positive bacterium; phosphatidic acid metabolic process; somatic stem cell maintenance; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; lipid catabolic process; positive regulation of inflammatory response; negative regulation of epithelial cell proliferation Disease: Colorectal Cancer |
| NCBI Summary: | The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009] |
| UniProt Code: | P14555 |
| NCBI GenInfo Identifier: | 129483 |
| NCBI Gene ID: | 5320 |
| NCBI Accession: | P14555.2 |
| UniProt Secondary Accession: | P14555,Q6DN24, Q6IBD9, Q9UCD2, A8K5I7, |
| UniProt Related Accession: | P14555 |
| Molecular Weight: | 144 |
| NCBI Full Name: | Phospholipase A2, membrane associated |
| NCBI Synonym Full Names: | phospholipase A2, group IIA (platelets, synovial fluid) |
| NCBI Official Symbol: | PLA2G2A |
| NCBI Official Synonym Symbols: | MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2 |
| NCBI Protein Information: | phospholipase A2, membrane associated; NPS-PLA2; GIIC sPLA2; group IIA phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A; non-pancreatic secretory phospholipase A2 |
| UniProt Protein Name: | Phospholipase A2, membrane associated |
| UniProt Synonym Protein Names: | GIIC sPLA2; Group IIA phospholipase A2; Non-pancreatic secretory phospholipase A2; NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2A |
| Protein Family: | Phospholipase |
| UniProt Gene Name: | PLA2G2A |
| UniProt Entry Name: | PA2GA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PLA2G2A antibody (CAB1234) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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