Metabolism Antibodies 3
Anti-PLA2G12A Antibody (CAB15902)
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- SKU:
- CAB15902
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-PLA2G12A Antibody |
| Antibody SKU: | CAB15902 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PLA2G12A (NP_110448.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HepG2, HeLa, Mouse pancreas |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PLA2G12A (NP_110448.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MALL SRPA LTLL LLLM AAVV RCQE QAQT TDWR ATLK TIRN GVHK IDTY LNAA LDLL GGED GLCQ YKCS DGSK PFPR YGYK PSPP NGCG SPLF GVHL NIGI |
| Gene ID: | 81579 |
| Uniprot: | Q9BZM1 |
| Cellular Location: | Cytoplasm, Secreted |
| Calculated MW: | 21kDa |
| Observed MW: | 17kDa |
| Synonyms: | PLA2G12A, GXII, PLA2G12, ROSSY |
| Background: | Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]). |
| UniProt Protein Function: | PLA2G12A: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine. Belongs to the phospholipase A2 family. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - glycerophospholipid; Secreted; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - linoleic acid; Secreted, signal peptide; EC 3.1.1.4; Lipid Metabolism - ether lipid; Lipid Metabolism - arachidonic acid; Endoplasmic reticulum; Phospholipase Chromosomal Location of Human Ortholog: 4q25 Cellular Component: extracellular region Molecular Function:phospholipase A2 activity Biological Process: phosphatidic acid biosynthetic process |
| NCBI Summary: | Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9BZM1 |
| NCBI GenInfo Identifier: | 20143881 |
| NCBI Gene ID: | 81579 |
| NCBI Accession: | Q9BZM1.1 |
| UniProt Secondary Accession: | Q9BZM1,Q9BZ89, |
| UniProt Related Accession: | Q9BZM1 |
| Molecular Weight: | 21,067 Da |
| NCBI Full Name: | Group XIIA secretory phospholipase A2 |
| NCBI Synonym Full Names: | phospholipase A2 group XIIA |
| NCBI Official Symbol: | PLA2G12A |
| NCBI Official Synonym Symbols: | GXII; ROSSY; PLA2G12 |
| NCBI Protein Information: | group XIIA secretory phospholipase A2 |
| UniProt Protein Name: | Group XIIA secretory phospholipase A2 |
| UniProt Synonym Protein Names: | Phosphatidylcholine 2-acylhydrolase 12A |
| Protein Family: | Group XIIA secretory phospholipase |
| UniProt Gene Name: | PLA2G12A |
| UniProt Entry Name: | PG12A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PLA2G12A antibody (CAB15902) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 150s. |
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