| UniProt Protein Function: | PKR: a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis. Controls the activation of several transcription factors such as NF-kappaB, p53 and Stats. Mediates apoptosis induced by many different stimuli, such as LPS, TNF-alpha, viral infection and serum starvation. |
| UniProt Protein Details: | Protein type:Translation; Kinase, protein; EC 2.7.10.2; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; PEK family Chromosomal Location of Human Ortholog: 2p22-p21 Cellular Component: membrane; perinuclear region of cytoplasm; cytoplasm; ribosome; nucleus; cytosol Molecular Function:protein serine/threonine kinase activity; protein binding; double-stranded RNA binding; non-membrane spanning protein tyrosine kinase activity; protein phosphatase type 2A regulator activity; ATP binding; eukaryotic translation initiation factor 2alpha kinase activity; protein kinase activity Biological Process: positive regulation of cytokine production; peptidyl-tyrosine phosphorylation; translation; activation of MAPKK activity; transcription, DNA-dependent; unfolded protein response; response to virus; protein amino acid autophosphorylation; viral infectious cycle; protein amino acid phosphorylation; positive regulation of stress-activated MAPK cascade; positive regulation of chemokine production; evasion by virus of host immune response; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; modification by virus of host cellular process; negative regulation of viral genome replication; virus-host interaction; negative regulation of translation; innate immune response; negative regulation of osteoblast proliferation; defense response to virus; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | P19525 |
| NCBI GenInfo Identifier: | 125527 |
| NCBI Gene ID: | 5610 |
| NCBI Accession: | P19525.2 |
| UniProt Secondary Accession: | P19525,Q52M43, Q7Z6F6, Q9UIR4, A8K3P0, D6W584, E9PC80 |
| UniProt Related Accession: | P19525 |
| Molecular Weight: | 62,094 Da |
| NCBI Full Name: | Interferon-induced, double-stranded RNA-activated protein kinase |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 2-alpha kinase 2 |
| NCBI Official Symbol: | EIF2AK2 |
| NCBI Official Synonym Symbols: | PKR; PRKR; EIF2AK1; PPP1R83 |
| NCBI Protein Information: | interferon-induced, double-stranded RNA-activated protein kinase; p68 kinase; eIF-2A protein kinase 2; P1/eIF-2A protein kinase; tyrosine-protein kinase EIF2AK2; interferon-inducible elF2alpha kinase; double stranded RNA activated protein kinase; protein phosphatase 1, regulatory subunit 83; protein kinase, interferon-inducible double stranded RNA dependent |
| UniProt Protein Name: | Interferon-induced, double-stranded RNA-activated protein kinase |
| UniProt Synonym Protein Names: | Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein kinase; Protein kinase RNA-activated; PKR; Tyrosine-protein kinase EIF2AK2 (EC:2.7.10.2); p68 kinase |
| UniProt Gene Name: | EIF2AK2 |
| UniProt Entry Name: | E2AK2_HUMAN |
