Anti-PKMYT1 Antibody (CAB20525)

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SKU:
CAB20525
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MYT1
Synonyms:
PPP1R126

Description

Product Name:PKMYT1 Rabbit pAb
Product Code:CAB20525
Size:50uL, 100uL
Synonyms:MYT1, PPP1R126
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human PKMYT1.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, Mouse testis, Mouse thymus, Rat testis
Immunogen:Recombinant protein of human PKMYT1.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9088
Uniprot:Q99640
Calculated MW:54kDa
Observed MW:54KDa
UniProt Protein Function:Myt1: a dual specificity protein kinase of the WEE family. Preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Alternative splice-variant isoforms have been reported.
UniProt Protein Details:

Protein type:Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor); EC 2.7.11.1; Other group; WEE family

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; membrane; nucleoplasm

Molecular Function:ATP binding; kinase activity; metal ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; mitosis; mitotic cell cycle; protein amino acid phosphorylation; regulation of cell cycle; regulation of cyclin-dependent protein kinase activity; regulation of mitosis

NCBI Summary:This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
UniProt Code:Q99640
NCBI GenInfo Identifier:55976573
NCBI Gene ID:9088
NCBI Accession:Q99640.1
UniProt Secondary Accession:Q99640,O14731, Q7LE24, Q8TCM9, B3KUN8, B4DXD4, D3DUA4 F8W164, I3L1V2,
UniProt Related Accession:Q99640
Molecular Weight:47,284 Da
NCBI Full Name:Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
NCBI Synonym Full Names:protein kinase, membrane associated tyrosine/threonine 1
NCBI Official Symbol:PKMYT1  
NCBI Official Synonym Symbols:MYT1; PPP1R126  
NCBI Protein Information:membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
UniProt Protein Name:Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
UniProt Synonym Protein Names:Myt1 kinase
Protein Family:Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
UniProt Gene Name:PKMYT1  
UniProt Entry Name:PMYT1_HUMAN
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