Signal Transduction Antibodies 2

Anti-PKD1L2 Antibody (CAB14954)

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SKU:
CAB14954
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-PKD1L2 Antibody
Antibody SKU:CAB14954
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-306 of human PKD1L2 (NP_001265352.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-306 of human PKD1L2 (NP_001265352.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGED SPVA MFSW YLDN TPTE QAEP LLDA CRLR GFWP RSLT LLQS NTST LLLN SSFL QSRG EVIR IRAT ALTR HAYG EDTY VIST VPPR EVPA CTIA PEEG TVLT SFAI FCNA STAL GPLE FCFC LESG SCLH CGPE PALP SVYL PLGE ENND FVLT VVIS ATNR AGDT QQTQ AMAK VALG DTCV EDVA FQAA VSEK IPTA LQGE GGPE QLLQ LAKA VSSM LNQE HESQ GSGQ SLSI DVRQ KVRE HVLG SLSA VTTG LEDV QRVQ ELAE VLRE VTCR SKEL TPSA QGSC MGDS WEGA PPAA HVSH AR
Gene ID:114780
Uniprot:Q7Z442
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:26kDa/32kDa/107kDa/197kDa/272kDa
Observed MW:33kDa
Synonyms:PKD1L2, PC1L2
Background:This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, where some individuals contain a non-functional allele. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:PKD1L2: May function as an ion-channel regulator. May function as a G-protein-coupled receptor. Belongs to the polycystin family. 7 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16q23.2

Cellular Component: integral to membrane

Molecular Function:calcium ion binding; carbohydrate binding

Biological Process: ion transport

NCBI Summary:This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, where some individuals contain a non-functional allele. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
UniProt Code:Q7Z442
NCBI GenInfo Identifier:116006953
NCBI Gene ID:114780
NCBI Accession:NP_001070248.1
UniProt Secondary Accession:Q7Z442,Q6UEE1, Q6ZN46, Q6ZSP2, Q8N1H9, Q96CL2, Q96Q08
UniProt Related Accession:Q7Z442
Molecular Weight:26,012 Da
NCBI Full Name:polycystic kidney disease protein 1-like 2 isoform c
NCBI Synonym Full Names:polycystic kidney disease 1-like 2 (gene/pseudogene)
NCBI Official Symbol:PKD1L2  
NCBI Official Synonym Symbols:PC1L2  
NCBI Protein Information:polycystic kidney disease protein 1-like 2
UniProt Protein Name:Polycystic kidney disease protein 1-like 2
UniProt Synonym Protein Names:PC1-like 2 protein; Polycystin-1L2
Protein Family:Polycystic kidney disease protein
UniProt Gene Name:PKD1L2  
UniProt Entry Name:PK1L2_HUMAN
Anti-PKD1L2 Antibody (CAB14954)Western blot analysis of extracts of mouse lung, using PKD1L2 antibody (CAB14954) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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