Cell Biology Antibodies 17
Anti-PKC epsilon Antibody (CAB4998)
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- SKU:
- CAB4998
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PKCE
- Synonyms:
- nPKC-epsilon
- Research Area:
- Cell Biology
Description
| Product Name: | PKC epsilon Rabbit mAb |
| Product Code: | CAB4998 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | PKCE, nPKC-epsilon |
| Applications: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PKC epsilon |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse lung |
| Immunogen: | A synthesized peptide derived from human PKC epsilon |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5581 |
| Uniprot: | Q02156 |
| Cellular Location: | Cell membrane, Cytoplasm, Nucleus, cytoskeleton, perinuclear region |
| Calculated MW: | 84kDa |
| Observed MW: | 82KDa |
| UniProt Protein Function: | PKCE: an AGC kinase of the PKC family. Calcium-independent, phospholipid-dependent. Activated by inflammatory mediators and involved in nociceptive functions. PKC-epsilon null mice display decreased hypoxic pulmonary vasoconstriction. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, AGC; EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Eta subfamily Chromosomal Location of Human Ortholog: 2p21 Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; Golgi apparatus; perinuclear region of cytoplasm; plasma membrane Molecular Function:actin monomer binding; enzyme activator activity; enzyme binding; protein binding; protein kinase C activity; protein serine/threonine kinase activity; signal transducer activity Biological Process: apoptosis; lipopolysaccharide-mediated signaling pathway; peptidyl-serine phosphorylation; phospholipase C activation; platelet activation; positive regulation of actin filament polymerization; positive regulation of cytokinesis; protein amino acid phosphorylation; signal transduction |
| NCBI Summary: | Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q02156 |
| NCBI GenInfo Identifier: | 400135 |
| NCBI Gene ID: | 5581 |
| NCBI Accession: | Q02156.1 |
| UniProt Secondary Accession: | Q02156,Q32MQ3, Q53SL4, Q53SM5, Q9UE81, B0LPH7, |
| UniProt Related Accession: | Q02156 |
| Molecular Weight: | 83,674 Da |
| NCBI Full Name: | Protein kinase C epsilon type |
| NCBI Synonym Full Names: | protein kinase C epsilon |
| NCBI Official Symbol: | PRKCE |
| NCBI Official Synonym Symbols: | PKCE; nPKC-epsilon |
| NCBI Protein Information: | protein kinase C epsilon type |
| UniProt Protein Name: | Protein kinase C epsilon type |
| UniProt Synonym Protein Names: | nPKC-epsilon |
| Protein Family: | Protein kinase |
| UniProt Gene Name: | PRKCE |
| UniProt Entry Name: | KPCE_HUMAN |
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