Signal Transduction Antibodies 3

Anti-PJA2 Antibody (CAB6444)

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SKU:
CAB6444
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-PJA2 Antibody
Antibody SKU:CAB6444
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 439-708 of human PJA2 (NP_055634.3).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 439-708 of human PJA2 (NP_055634.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SLPH RFSG TEKD QSSS DESW ETLP GKDE NEPE LQSD SSGP EEEN QELS LQEG EQTS LEEG EIPW LQYN EVNE SSSD EGNE PANE FAQP AFML DGNN NLED DSSV SEDL DVDW SLFD GFAD GLGV AEAI SYVD PQFL TYMA LEER LAQA META LAHL ESLA VDVE VANP PASK ESID GLPE TLVL EDHT AIGQ EQCC PICC SEYI KDDI ATEL PCHH FFHK PCVS IWLQ KSGT CPVC RRHF PPAV IEAS AAPS SEPD PDAP PSND SIAE AP
Gene ID:9867
Uniprot:O43164
Cellular Location:Cell junction, Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Golgi apparatus membrane, Peripheral membrane protein, postsynaptic cell membrane, postsynaptic density, synapse
Calculated MW:76kDa/78kDa
Observed MW:Refer to Figures
Synonyms:PJA2, Neurodap1, RNF131
Background:
UniProt Protein Function:PJA2: Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA- mediated long-term memory processes. Binds ubiquitin-conjugating enzymes (E2s). In vitro, interacts with the ubiquitin-conjugating enzyme, UBE2D2. The phosphorylated form interacts with PRKAR1A, PRKAR2A and PRKAR2B. Binds the catalytic subunits of cAMP-dependent protein kinase. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 5q21.3

Cellular Component: Golgi membrane; postsynaptic membrane; endoplasmic reticulum membrane; cytoplasm; postsynaptic density; plasma membrane; cell junction

Molecular Function:zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: long-term memory; protein ubiquitination

UniProt Code:O43164
NCBI GenInfo Identifier:269849763
NCBI Gene ID:9867
NCBI Accession:O43164.4
UniProt Secondary Accession:O43164,Q68D49, Q8N1G5, A8K6U4, D3DSZ5,
UniProt Related Accession:O43164
Molecular Weight:708
NCBI Full Name:E3 ubiquitin-protein ligase Praja-2
NCBI Synonym Full Names:praja ring finger 2, E3 ubiquitin protein ligase
NCBI Official Symbol:PJA2  
NCBI Official Synonym Symbols:RNF131; Neurodap1  
NCBI Protein Information:E3 ubiquitin-protein ligase Praja-2; praja2; ring finger protein 131; praja 2, RING-H2 motif containing
UniProt Protein Name:E3 ubiquitin-protein ligase Praja-2
UniProt Synonym Protein Names:RING finger protein 131
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:PJA2  
UniProt Entry Name:PJA2_HUMAN
Anti-PJA2 Antibody (CAB6444)Immunofluorescence analysis of U2OS cells using PJA2 antibody (CAB6444). Blue: DAPI for nuclear staining.
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