Epigenetics & Nuclear Signaling Antibodies 3

Anti-PITX1 Antibody (CAB4022)

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SKU:
CAB4022
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-PITX1 Antibody
Antibody SKU:CAB4022
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human PITX1 (NP_002644.4).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human PITX1 (NP_002644.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDAF KGGM SLER LPEG LRPP PPPP HDMG PAFH LARP ADPR EPLE NSAS ESSD TELP EKER GGEP KGPE DSGA GGTG CGGA
Gene ID:5307
Uniprot:P78337
Cellular Location:Nucleus
Calculated MW:34kDa
Observed MW:40kDa
Synonyms:PITX1, BFT, CCF, LBNBG, POTX, PTX1
Background:This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.
UniProt Protein Function:PITX1: May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Defects in PITX1 are a cause of congenital clubfoot (CCF); also known as talipes equinovarus (TEV). Clubfoot is a congenital limb deformity defined as fixation of the foot in cavus, adductus, varus, and equinus (i.e. inclined inwards, axially rotated outwards, and pointing downwards) with concomitant soft tissue abnormalities. Clubfoot may occur in isolation or as part of a syndrome. Clubfoot appears to be a multifactorial trait. Belongs to the paired homeobox family. Bicoid subfamily.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: nucleolus; nucleus

Molecular Function:protein binding

Biological Process: anatomical structure morphogenesis; skeletal development

Disease: Clubfoot, Congenital, With Or Without Deficiency Of Long Bones And/or Mirror-image Polydactyly; Liebenberg Syndrome

NCBI Summary:This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008]
UniProt Code:P78337
NCBI GenInfo Identifier:108935922
NCBI Gene ID:5307
NCBI Accession:P78337.2
UniProt Secondary Accession:P78337,O14677, O60425, Q9BTI5, A8K3M0, D3DQB0,
UniProt Related Accession:P78337
Molecular Weight:34,128 Da
NCBI Full Name:Pituitary homeobox 1
NCBI Synonym Full Names:paired like homeodomain 1
NCBI Official Symbol:PITX1  
NCBI Official Synonym Symbols:BFT; CCF; POTX; PTX1; LBNBG  
NCBI Protein Information:pituitary homeobox 1
UniProt Protein Name:Pituitary homeobox 1
UniProt Synonym Protein Names:Hindlimb-expressed homeobox protein backfoot; Homeobox protein PITX1; Paired-like homeodomain transcription factor 1
Protein Family:Pituitary homeobox
UniProt Gene Name:PITX1  
UniProt Entry Name:PITX1_HUMAN
Anti-PITX1 Antibody (CAB4022)Western blot analysis of extracts of rat pancreas, using PITX1 antibody (CAB4022) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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