Cell Biology Antibodies 3
Anti-PIP4K2B Antibody (CAB12535)
- SKU:
- CAB12535
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-PIP4K2B Antibody |
Antibody SKU: | CAB12535 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PIP4K2B (NP_003550.1). |
Application: | WB IF |
Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | HeLa, BT-474, A-549, Mouse spleen |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PIP4K2B (NP_003550.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MSSN CTST TAVA VAPL SASK TKTK KKHF VCQK VKLF RASE PILS VLMW GVNH TINE LSNV PVPV MLMP DDFK AYSK IKVD NHLF NKEN LPSR FKFK EYCP MVFR NLRE RFGI DDQD YQNS VTRS APIN SDSQ GRCG TRFL TTYD RRFV IKTV SSED VAEM HNIL KKYH QFIV ECHG NTLL PQFL GMYR LTVD GVET YMVV TRNV FSHR LTVH RKYD LKGS TVAR EASD KEKA KDLP TFKD NDFL NEGQ KLHV GEES KKNF LEKL KRDV EF |
Gene ID: | 8396 |
Uniprot: | P78356 |
Cellular Location: | Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Nucleus, Peripheral membrane protein |
Calculated MW: | 32kDa/47kDa |
Observed MW: | 47kDa |
Synonyms: | PIP4K2B, PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta, PIP5P4KB |
Background: | The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5, 4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. |
UniProt Protein Function: | PIP4K2B: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex. Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Kinase, lipid; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q12 Cellular Component: autophagic vacuole; cytosol; nucleoplasm Molecular Function:1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; protein binding; protein homodimerization activity; receptor signaling protein activity Biological Process: cell surface receptor linked signal transduction; phosphatidylinositol biosynthetic process; phospholipid metabolic process; regulation of autophagy; regulation of phosphoinositide 3-kinase cascade |
NCBI Summary: | The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008] |
UniProt Code: | P78356 |
NCBI GenInfo Identifier: | 47605991 |
NCBI Gene ID: | 8396 |
NCBI Accession: | P78356.1 |
UniProt Secondary Accession: | P78356,Q5U0E8, Q8TBP2, |
UniProt Related Accession: | P78356 |
Molecular Weight: | Calculated MW: 32kDa/47kDaObserved MW: 47kDa |
NCBI Full Name: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
NCBI Synonym Full Names: | phosphatidylinositol-5-phosphate 4-kinase type 2 beta |
NCBI Official Symbol: | PIP4K2B |
NCBI Official Synonym Symbols: | PI5P4KB; PIP5K2B; PIP5KIIB; PIP5P4KB; PIP5KIIbeta |
NCBI Protein Information: | phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
UniProt Protein Name: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
UniProt Synonym Protein Names: | 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; Phosphatidylinositol 5-phosphate 4-kinase type II beta; PI(5)P 4-kinase type II beta; PIP4KII-beta; PtdIns(5)P-4-kinase isoform 2-beta |
Protein Family: | Phosphatidylinositol 5-phosphate 4-kinase |
UniProt Gene Name: | PIP4K2B |
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