Cell Biology Antibodies 13

Anti-PINX1 Antibody (CAB17172)

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SKU:
CAB17172
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PINX1 Antibody
Antibody SKU:CAB17172
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 127-328 of human PINX1 (NP_060354.4).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, Jurkat, HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 127-328 of human PINX1 (NP_060354.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKFT KGKD LSSR SKTD LDCI FGKR QSKK TPEG DASP STPE ENET TTTS AFTI QEYF AKRM AALK NKPQ VPVP GSDI SETQ VERK RGKK RNKE ATGK DVES YLQP KAKR HTEG KPER AEAQ ERVA KKKS APAE EQLR GPCW DQSS KASA QDAG DHVQ PPEG RDFT LKPK KRRG KKKL QKPV EIAE DATL EETL VKKK KKKD SK
Gene ID:54984
Uniprot:Q96BK5
Cellular Location:
Calculated MW:19kDa/37kDa
Observed MW:43kDa
Anti-PINX1 Antibody (CAB17172)Western blot - PINX1 Polyclonal Antibody (CAB17172)
Synonyms:PINX1, LPTL, LPTS
Background:
UniProt Protein Function:PINX1: Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. Belongs to the PINX1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nucleolus; Tumor suppressor; Inhibitor

Chromosomal Location of Human Ortholog: 8p23

Cellular Component: cytoplasm; intracellular membrane-bound organelle; kinetochore; mitochondrion; nuclear chromosome; nuclear chromosome, telomeric region; nucleolus; nucleus; spindle

Molecular Function:protein binding

Biological Process: mitotic metaphase plate congression; negative regulation of cell proliferation; negative regulation of protein ubiquitination; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; regulation of protein stability; regulation of telomerase activity; telomere maintenance via telomerase

UniProt Code:Q96BK5
NCBI GenInfo Identifier:547234890
NCBI Gene ID:54984
NCBI Accession:NP_001271285.1
UniProt Secondary Accession:Q96BK5,Q548A5, Q6QWG9, Q7Z7J8, Q96QD7, Q9HBU7, Q9NWW2 B2R9B1,
UniProt Related Accession:Q96BK5
Molecular Weight:19,714 Da
NCBI Full Name:PIN2/TERF1-interacting telomerase inhibitor 1 isoform 2
NCBI Synonym Full Names:PIN2/TERF1 interacting, telomerase inhibitor 1
NCBI Official Symbol:PINX1  
NCBI Official Synonym Symbols:LPTL; LPTS  
NCBI Protein Information:PIN2/TERF1-interacting telomerase inhibitor 1
UniProt Protein Name:PIN2/TERF1-interacting telomerase inhibitor 1
UniProt Synonym Protein Names:Liver-related putative tumor suppressor; Pin2-interacting protein X1; Protein 67-11-3; TRF1-interacting protein 1
Protein Family:PIN2/TERF1-interacting telomerase inhibitor
UniProt Gene Name:PINX1  
UniProt Entry Name:PINX1_HUMAN
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