Immunology Antibodies 2

Anti-PILRA Antibody (CAB17292)

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SKU:
CAB17292
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-PILRA Antibody
Antibody SKU:CAB17292
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human PILRA.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse liver, Rat liver
Immunogen:Recombinant protein of human PILRA.
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:29992
Uniprot:Q9UKJ1
Cellular Location:
Calculated MW:34kDa
Observed MW:45kDa
Synonyms:PILRA, FDF03
Background:Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
UniProt Protein Function:PILRA: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function:protein binding

Biological Process: viral reproduction; signal transduction

NCBI Summary:Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UKJ1
NCBI GenInfo Identifier:30179909
NCBI Gene ID:29992
NCBI Accession:NP_038467.2
UniProt Secondary Accession:Q9UKJ1,Q8NHI1,
UniProt Related Accession:Q9UKJ1
Molecular Weight:34,005 Da
NCBI Full Name:paired immunoglobulin-like type 2 receptor alpha isoform 1
NCBI Synonym Full Names:paired immunoglobin-like type 2 receptor alpha
NCBI Official Symbol:PILRA  
NCBI Official Synonym Symbols:FDF03  
NCBI Protein Information:paired immunoglobulin-like type 2 receptor alpha; cell surface receptor FDF03; inhibitory receptor PILR-alpha
UniProt Protein Name:Paired immunoglobulin-like type 2 receptor alpha
UniProt Synonym Protein Names:Cell surface receptor FDF03; Inhibitory receptor PILR-alpha
Protein Family:Paired immunoglobulin-like type 2 receptor
UniProt Gene Name:PILRA  
UniProt Entry Name:PILRA_HUMAN
Anti-PILRA Antibody (CAB17292)Western blot analysis of extracts of various cell lines, using PILRA Rabbit pAb (CAB17292) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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