Cell Biology Antibodies 9
Anti-PIGR Antibody (CAB6130)
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- SKU:
- CAB6130
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PIGR Antibody |
| Antibody SKU: | CAB6130 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 661-764 of human PIGR (NP_002635.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, LO2, 293T, A-549, SGC-7901, Mouse liver, Rat intestine, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 661-764 of human PIGR (NP_002635.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ARAR HRKN VDRV SIRS YRTD ISMS DFEN SREF GAND NMGA SSIT QETS LGGK EEFV ATTE STTE TKEP KKAK RSSK EEAE MAYK DFLL QSST VAAE AQDG PQEA |
| Gene ID: | 5284 |
| Uniprot: | P01833 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 83kDa |
| Observed MW: | 110kDa |
| Synonyms: | PIGR |
| Background: | This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene. |
| UniProt Protein Function: | PIGR: This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. |
| UniProt Protein Details: | Protein type:Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q31-q41 Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; receptor complex Molecular Function:polymeric immunoglobulin receptor activity Biological Process: epidermal growth factor receptor signaling pathway; retinal homeostasis; detection of chemical stimulus involved in sensory perception of bitter taste; receptor clustering; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor Disease: Iga Nephropathy, Susceptibility To, 1 |
| NCBI Summary: | This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009] |
| UniProt Code: | P01833 |
| NCBI GenInfo Identifier: | 150421625 |
| NCBI Gene ID: | 5284 |
| NCBI Accession: | P01833.4 |
| UniProt Secondary Accession: | P01833,Q68D81, Q8IZY7, |
| UniProt Related Accession: | P01833 |
| Molecular Weight: | 764 |
| NCBI Full Name: | Polymeric immunoglobulin receptor |
| NCBI Synonym Full Names: | polymeric immunoglobulin receptor |
| NCBI Official Symbol: | PIGR |
| NCBI Protein Information: | polymeric immunoglobulin receptor; poly-Ig receptor; hepatocellular carcinoma associated protein TB6; hepatocellular carcinoma-associated protein TB6 |
| UniProt Protein Name: | Polymeric immunoglobulin receptor |
| UniProt Synonym Protein Names: | Hepatocellular carcinoma-associated protein TB6Secretory component |
| Protein Family: | Polymeric immunoglobulin receptor |
| UniProt Gene Name: | PIGR |
| UniProt Entry Name: | PIGR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PIGR antibody (CAB6130) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using PIGR antibody (CAB6130) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon using PIGR antibody (CAB6130) at dilution of 1:100 (40x lens). |
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