Metabolism Antibodies 1

Anti-PIGP Antibody (CAB15446)

(No reviews yet) Write a Review
SKU:
CAB15446
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-PIGP Antibody
Antibody SKU:CAB15446
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-158 of human PIGP (NP_710148.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-158 of human PIGP (NP_710148.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVEN SPSP LPER AIYG FVLF LSSQ FGFI LYLV WAFI PESW LNSL GLTY WPQK YWAV ALPV YLLI AIVI GYVL LFGI NMMS TSPL DSIH TITD NYAK NQQQ KKYQ EEAI PALR DISI SEVN QMFF LAAK ELYT KN
Gene ID:51227
Uniprot:P57054
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:12kDa/15kDa/18kDa
Observed MW:22kDa
Synonyms:PIGP, DCRC, DCRC-S, DSCR5, DSRC, PIG-P
Background:This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described.
UniProt Protein Function:PIGP: Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Belongs to the PIGP family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Transferase; EC 2.4.1.198

Chromosomal Location of Human Ortholog: 21q22.2

Cellular Component: endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

Molecular Function:phosphatidylinositol N-acetylglucosaminyltransferase activity

Biological Process: preassembly of GPI anchor in ER membrane

NCBI Summary:This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]
UniProt Code:P57054
NCBI GenInfo Identifier:425906062
NCBI Gene ID:51227
NCBI Accession:P57054.3
UniProt Secondary Accession:P57054,Q53Y28, Q96KI1, Q9NZA6, B2RB18, B2RE99, B5BU92 D3DSG7, J3KR75,
UniProt Related Accession:P57054
Molecular Weight:12,510 Da
NCBI Full Name:Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
NCBI Synonym Full Names:phosphatidylinositol glycan anchor biosynthesis class P
NCBI Official Symbol:PIGP  
NCBI Official Synonym Symbols:DCRC; DSRC; DSCR5; PIG-P; DCRC-S  
NCBI Protein Information:phosphatidylinositol N-acetylglucosaminyltransferase subunit P
UniProt Protein Name:Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
UniProt Synonym Protein Names:Down syndrome critical region protein 5; Down syndrome critical region protein C; Phosphatidylinositol-glycan biosynthesis class P protein; PIG-P
UniProt Gene Name:PIGP  
UniProt Entry Name:PIGP_HUMAN
Anti-PIGP Antibody (CAB15446)Western blot analysis of extracts of mouse brain, using PIGP antibody (CAB15446) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
View AllClose

0 Reviews

View AllClose

Related Products