Cell Biology Antibodies 15

Anti-PIGO Antibody (CAB18670)

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SKU:
CAB18670
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PIGO Antibody
Antibody SKU:CAB18670
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human PIGO.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, 22Rv1, Mouse uterus, Mouse spleen
Immunogen:Recombinant protein of human PIGO.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:84720
Uniprot:Q8TEQ8
Cellular Location:Endoplasmic reticulum membrane, Multi-pass membrane protein
Calculated MW:73kDa/118kDa
Observed MW:119kDa
Anti-PIGO Antibody (CAB18670)Western blot - PIGO Rabbit pAb (CAB18670)
Synonyms:PIGO, HPMRS2, GPI ethanolamine phosphate transferase 3
Background:This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein is involved in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least three alternatively spliced transcripts encoding two distinct isoforms have been found for this gene.
UniProt Protein Function:PIGO: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond. Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Transferase; Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral; EC 2.-.-.-

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: endoplasmic reticulum membrane; membrane

Molecular Function:mannose-ethanolamine phosphotransferase activity

Biological Process: GPI anchor biosynthetic process

Disease: Hyperphosphatasia With Mental Retardation Syndrome 2

NCBI Summary:This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein is involved in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least three alternatively spliced transcripts encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
UniProt Code:Q8TEQ8
NCBI GenInfo Identifier:61252289
NCBI Gene ID:84720
NCBI Accession:Q8TEQ8.3
UniProt Secondary Accession:Q8TEQ8,Q6P154, Q6UX80, Q8TDS8, Q96CS9, Q9BVN9, Q9Y4B0 B1AML3,
UniProt Related Accession:Q8TEQ8
Molecular Weight:73,992 Da
NCBI Full Name:GPI ethanolamine phosphate transferase 3
NCBI Synonym Full Names:phosphatidylinositol glycan anchor biosynthesis class O
NCBI Official Symbol:PIGO  
NCBI Official Synonym Symbols:HPMRS2  
NCBI Protein Information:GPI ethanolamine phosphate transferase 3
UniProt Protein Name:GPI ethanolamine phosphate transferase 3
UniProt Synonym Protein Names:Phosphatidylinositol-glycan biosynthesis class O protein; PIG-O
UniProt Gene Name:PIGO  
UniProt Entry Name:PIGO_HUMAN
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