Name: Anti-PIGM Antibody (CAB17811)
Brand: Cell Biology Antibodies 15
SKU: CAB17811
Availability: OutOfStock

Antibody Name:	Anti-PIGM Antibody
Antibody SKU:	CAB17811
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 35-96 of human PIGM (NP_660150.1).

Application:	WB IHC IF
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	BxPC-3, Mouse thymus, Mouse spleen, Mouse lung, Rat thymus, Rat spleen

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 35-96 of human PIGM (NP_660150.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	YGVF QDRT LHVR YTDI DYQV FTDA ARFV TEGR SPYL RATY RYTP LLGW LLTP NIYL SELF GK
Gene ID:	93183
Uniprot:	Q9H3S5
Cellular Location:
Calculated MW:
Observed MW:	49kDa

Western blot - PIGM Rabbit pAb (CAB17811)

Synonyms:

GPI-MT-I, PIGM

Background:

This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]

UniProt Protein Function:	PIGM: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Defects in PIGM are the cause of glycosylphosphatidylinositol deficiency (GPID). GPID is an autosomal recessive trait that results in a propensity to venous thrombosis and seizures. Deficiency is due to a point mutation in the regulatory sequences of PIGM that disrupts binding of the transcription factor SP1 to its cognate promoter motif, leading to a strong reduction of expression. Belongs to the PIGM family.
UniProt Protein Details:	Protein type:Transferase; EC 2.4.1.-; Membrane protein, multi-pass; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q23.2 Cellular Component: endoplasmic reticulum membrane Biological Process: preassembly of GPI anchor in ER membrane Disease: Glycosylphosphatidylinositol Deficiency
NCBI Summary:	This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9H3S5
NCBI GenInfo Identifier:	74752622
NCBI Gene ID:	93183
NCBI Accession:	Q9H3S5.1
UniProt Related Accession:	Q9H3S5
Molecular Weight:	49,460 Da
NCBI Full Name:	GPI mannosyltransferase 1
NCBI Synonym Full Names:	phosphatidylinositol glycan anchor biosynthesis class M
NCBI Official Symbol:	PIGM
NCBI Official Synonym Symbols:	GPI-MT-I
NCBI Protein Information:	GPI mannosyltransferase 1
UniProt Protein Name:	GPI mannosyltransferase 1
UniProt Synonym Protein Names:	GPI mannosyltransferase I; GPI-MT-I; Phosphatidylinositol-glycan biosynthesis class M protein; PIG-M
Protein Family:	Pigment-dispersing hormone
UniProt Gene Name:	PIGM
UniProt Entry Name:	PIGM_HUMAN