Cell Biology Antibodies 15
Anti-PIGM Antibody (CAB17811)
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- SKU:
- CAB17811
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PIGM Antibody |
| Antibody SKU: | CAB17811 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-96 of human PIGM (NP_660150.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BxPC-3, Mouse thymus, Mouse spleen, Mouse lung, Rat thymus, Rat spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-96 of human PIGM (NP_660150.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YGVF QDRT LHVR YTDI DYQV FTDA ARFV TEGR SPYL RATY RYTP LLGW LLTP NIYL SELF GK |
| Gene ID: | 93183 |
| Uniprot: | Q9H3S5 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 49kDa |
 | Western blot - PIGM Rabbit pAb (CAB17811) |
| Synonyms: | GPI-MT-I, PIGM |
| Background: | This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | PIGM: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Defects in PIGM are the cause of glycosylphosphatidylinositol deficiency (GPID). GPID is an autosomal recessive trait that results in a propensity to venous thrombosis and seizures. Deficiency is due to a point mutation in the regulatory sequences of PIGM that disrupts binding of the transcription factor SP1 to its cognate promoter motif, leading to a strong reduction of expression. Belongs to the PIGM family. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.4.1.-; Membrane protein, multi-pass; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q23.2 Cellular Component: endoplasmic reticulum membrane Biological Process: preassembly of GPI anchor in ER membrane Disease: Glycosylphosphatidylinositol Deficiency |
| NCBI Summary: | This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H3S5 |
| NCBI GenInfo Identifier: | 74752622 |
| NCBI Gene ID: | 93183 |
| NCBI Accession: | Q9H3S5.1 |
| UniProt Related Accession: | Q9H3S5 |
| Molecular Weight: | 49,460 Da |
| NCBI Full Name: | GPI mannosyltransferase 1 |
| NCBI Synonym Full Names: | phosphatidylinositol glycan anchor biosynthesis class M |
| NCBI Official Symbol: | PIGM |
| NCBI Official Synonym Symbols: | GPI-MT-I |
| NCBI Protein Information: | GPI mannosyltransferase 1 |
| UniProt Protein Name: | GPI mannosyltransferase 1 |
| UniProt Synonym Protein Names: | GPI mannosyltransferase I; GPI-MT-I; Phosphatidylinositol-glycan biosynthesis class M protein; PIG-M |
| Protein Family: | Pigment-dispersing hormone |
| UniProt Gene Name: | PIGM |
| UniProt Entry Name: | PIGM_HUMAN |
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