Name: Anti-PI4KA Antibody (CAB19329)
Brand: Cell Biology Antibodies 15
SKU: CAB19329
Availability: OutOfStock

Antibody Name:	Anti-PI4KA Antibody
Antibody SKU:	CAB19329
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant protein of human PI4KA.

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa, NIH/3T3, Mouse brain, Rat brain

Immunogen:	Recombinant protein of human PI4KA.
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	5297
Uniprot:	P42356
Cellular Location:
Calculated MW:	237kDa
Observed MW:	237kDa

Western blot - PI4KA Rabbit pAb (CAB19329)

Synonyms:

PIK4CA, PMGYCHA, pi4K230, PI4K-ALPHA, PI4KA

Background:

This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4, 5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

UniProt Protein Function:	PIK4CA: Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes. This is a type II PtdIns-4-kinase activated by detergents such as triton and inhibited by adenosine. Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; Kinase, lipid; EC 2.7.1.67; Carbohydrate Metabolism - inositol phosphate Chromosomal Location of Human Ortholog: 22q11.21 Cellular Component: focal adhesion; membrane; plasma membrane; cytosol Molecular Function:1-phosphatidylinositol 4-kinase activity; protein binding; ATP binding Biological Process: phosphoinositide-mediated signaling; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; signal transduction Disease: Polymicrogyria, Perisylvian, With Cerebellar Hypoplasia And Arthrogryposis
NCBI Summary:	This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014]
UniProt Code:	P42356
NCBI GenInfo Identifier:	218512114
NCBI Gene ID:	5297
NCBI Accession:	P42356.3
UniProt Secondary Accession:	P42356,Q7Z625, Q9UPG2,
UniProt Related Accession:	P42356
Molecular Weight:	96,984 Da
NCBI Full Name:	Phosphatidylinositol 4-kinase alpha
NCBI Synonym Full Names:	phosphatidylinositol 4-kinase, catalytic, alpha
NCBI Official Symbol:	PI4KA
NCBI Official Synonym Symbols:	PIK4CA; pi4K230; PI4K-ALPHA
NCBI Protein Information:	phosphatidylinositol 4-kinase alpha
UniProt Protein Name:	Phosphatidylinositol 4-kinase alpha
Protein Family:	Phosphatidylinositol 4-kinase
UniProt Gene Name:	PI4KA
UniProt Entry Name:	PI4KA_HUMAN