Description
| Product Name: | Phospholipid Scramblase 1 (PLSCR1) Rabbit mAb |
| Product Code: | CAB3430 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | MMTRA1B |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Phospholipid Phospholipid Scramblase 1 (PLSCR1) (PLSCR1) |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, Mouse lung |
| Immunogen: | A synthesized peptide derived from human Phospholipid Phospholipid Scramblase 1 (PLSCR1) (PLSCR1) |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5359 |
| Uniprot: | O15162 |
| Cellular Location: | Cell membrane, Cytoplasmic side, Lipid-anchor, Membrane, Nucleus, Single-pass type II membrane protein |
| Calculated MW: | 35kDa |
| Observed MW: | 35kDa |
| UniProt Protein Function: | PLSCR1: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Belongs to the phospholipid scramblase family. |
| UniProt Protein Details: | Protein type:Calcium-binding; Membrane protein, integral Chromosomal Location of Human Ortholog: 3q23 Cellular Component: extracellular matrix; Golgi apparatus; membrane; integral to plasma membrane; nucleolus; plasma membrane; cytosol; nucleus; lipid raft Molecular Function:phospholipid scramblase activity; protein binding; enzyme binding; DNA binding; calcium ion binding; CD4 receptor binding; SH3 domain binding; epidermal growth factor receptor binding Biological Process: platelet activation; negative regulation of viral genome replication; apoptosis; positive regulation of innate immune response; acute-phase response; positive regulation of transcription from RNA polymerase II promoter; phospholipid scrambling; defense response to virus; regulation of mast cell activation; phosphatidylserine biosynthetic process |
| UniProt Code: | O15162 |
| NCBI GenInfo Identifier: | 14548191 |
| NCBI Gene ID: | 5359 |
| NCBI Accession: | O15162.1 |
| UniProt Secondary Accession: | O15162,B2R8H8, B4DTE8, |
| UniProt Related Accession: | O15162 |
| Molecular Weight: | 318 |
| NCBI Full Name: | Phospholipid scramblase 1 |
| NCBI Synonym Full Names: | phospholipid scramblase 1 |
| NCBI Official Symbol: | PLSCR1Â Â |
| NCBI Official Synonym Symbols: | MMTRA1BÂ Â |
| NCBI Protein Information: | phospholipid scramblase 1; PL scramblase 1; erythrocyte phospholipid scramblase; ca(2+)-dependent phospholipid scramblase 1 |
| UniProt Protein Name: | Phospholipid scramblase 1 |
| UniProt Synonym Protein Names: | Ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; MmTRA1b |
| Protein Family: | Phospholipid scramblase |
| UniProt Gene Name: | PLSCR1Â Â |
| UniProt Entry Name: | PLS1_HUMAN |
