Epigenetics & Nuclear Signaling Antibodies 5
Anti-Phospho-WWTR1-S89 Antibody (CABP0919)
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- SKU:
- CABP0919
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-Phospho-WWTR1-S89 Antibody |
| Antibody SKU: | CABP0919 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around S89 of human WWTR1. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | A synthetic phosphorylated peptide around S89 of human WWTR1. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 25937 |
| Uniprot: | Q9GZV5 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 44kDa |
| Observed MW: | Refer to Figures |
| Synonyms: | WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif, TAZ, WWTR1 |
| Background: | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. |
| UniProt Protein Function: | TAZ: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP. Interacts (via coiled-coil domain) with SMAD2 (via MH1 domain), SMAD3 and SMAD4. Interacts with MED15, PAX8 and NKX2-1. Interacts with TEAD1, TEAD2, TEAD3 and TEAD4. Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue. |
| UniProt Protein Details: | Protein type:Oncoprotein; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 3q23-q24 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:protein binding; transcription coactivator activity Biological Process: negative regulation of protein amino acid phosphorylation; negative regulation of protein kinase activity; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; stem cell division; transcription initiation from RNA polymerase II promoter |
| UniProt Code: | Q9GZV5 |
| NCBI GenInfo Identifier: | 67462080 |
| NCBI Gene ID: | 25937 |
| NCBI Accession: | Q9GZV5.1 |
| UniProt Secondary Accession: | Q9GZV5,Q8N3P2, Q9Y3W6, D3DNH7, |
| UniProt Related Accession: | Q9GZV5 |
| Molecular Weight: | 44,101 Da |
| NCBI Full Name: | WW domain-containing transcription regulator protein 1 |
| NCBI Synonym Full Names: | WW domain containing transcription regulator 1 |
| NCBI Official Symbol: | WWTR1 |
| NCBI Official Synonym Symbols: | TAZ |
| NCBI Protein Information: | WW domain-containing transcription regulator protein 1 |
| UniProt Protein Name: | WW domain-containing transcription regulator protein 1 |
| UniProt Synonym Protein Names: | Transcriptional coactivator with PDZ-binding motif |
| Protein Family: | WW domain-containing transcription regulator protein |
| UniProt Gene Name: | WWTR1 |
| UniProt Entry Name: | WWTR1_HUMAN |
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