Anti-Phospho-WNK1-T60 Antibody (CABP1229)

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SKU:
CABP1229
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
WNK1
Synonyms:
HSAN2
Synonyms:
HSN2
Synonyms:
KDP
Synonyms:
PPP1R167
Synonyms:
PRKWNK1
Synonyms:
PSK
Synonyms:
p65
Research Area:
Cell Biology

Description

Product Name:Phospho-WNK1-T60 Rabbit pAb
Product Code:CABP1229
Size:50uL, 100uL
Synonyms:WNK1, HSAN2, HSN2, KDP, PPP1R167, PRKWNK1, PSK, p65
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic phosphorylated peptide around T60 of human WNK1 (NP_001171914.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:A synthetic phosphorylated peptide around T60 of human WNK1 (NP_001171914.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:65125
Uniprot:Q9H4A3
Calculated MW:206kDa/225kDa/250kDa/279kDa/299kDa
Observed MW:Refer to figures
UniProt Protein Function:WNK1: a serine-threonine protein kinase that controls sodium and chloride ion transport. May regulate the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation. May also play a role in actin cytoskeletal reorganization.
UniProt Protein Details:

Protein type:EC 2.7.11.1; Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; Wnk family

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: cytoplasm

Molecular Function:protein serine/threonine kinase activity; protein binding; chloride channel inhibitor activity; protein kinase inhibitor activity; ATP binding; phosphatase binding

Biological Process: regulation of cellular process; peptidyl-threonine phosphorylation; negative regulation of protein kinase activity; neuron development; ion transport; protein amino acid phosphorylation

Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iia; Pseudohypoaldosteronism, Type Iic

NCBI Summary:This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
UniProt Code:Q9H4A3
NCBI GenInfo Identifier:296453029
NCBI Gene ID:65125
NCBI Accession:Q9H4A3.2
UniProt Secondary Accession:Q9H4A3,O15052, P54963, Q4VBX9, Q6IFS5, Q86WL5, Q8N673 A1L4B0, C5HTZ5, C5HTZ6, C5HTZ7, H6WZW3,
UniProt Related Accession:Q9H4A3
Molecular Weight:2382
NCBI Full Name:Serine/threonine-protein kinase WNK1
NCBI Synonym Full Names:WNK lysine deficient protein kinase 1
NCBI Official Symbol:WNK1  
NCBI Official Synonym Symbols:KDP; PSK; p65; HSN2; HSAN2; PRKWNK1; PPP1R167  
NCBI Protein Information:serine/threonine-protein kinase WNK1; erythrocyte 65 kDa protein; protein kinase with no lysine 1; prostate-derived sterile 20-like kinase; WNK lysine deficient protein kinase 1 isoform; protein phosphatase 1, regulatory subunit 167
UniProt Protein Name:Serine/threonine-protein kinase WNK1
UniProt Synonym Protein Names:Erythrocyte 65 kDa protein; p65; Kinase deficient protein; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; hWNK1
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:WNK1  
UniProt Entry Name:WNK1_HUMAN
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