Anti-Phospho-VAV1-Y174 Antibody (CABP0180)
- SKU:
- CABP0180
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- VAV1
- Synonyms:
- VAV
- Research Area:
- Cell Biology
Description
| Product Name: | Phospho-VAV1-Y174 Rabbit pAb |
| Product Code: | CABP0180 |
| Size: | 50uL, 100uL |
| Synonyms: | VAV1, VAV |
| Applications: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Y174 of human VAV1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | Jurkat |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Y174 of human VAV1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7409 |
| Uniprot: | P15498 |
| Calculated MW: | 94kDa/98kDa |
| Observed MW: | 98kDa |
| UniProt Protein Function: | VAV1: a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed exclusively in hematopoietic cells. Important in hematopoiesis, playing a role in T-cell and B-cell development and activation. |
| UniProt Protein Details: | Protein type:GEFs, Rac/Rho; GEFs; Oncoprotein; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: plasma membrane; intercellular junction; cytosol Molecular Function:protein binding; metal ion binding; Rac guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; transcription factor activity Biological Process: epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; neutrophil chemotaxis; platelet activation; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; T cell activation; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; G-protein coupled receptor protein signaling pathway; regulation of small GTPase mediated signal transduction; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; T cell costimulation; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P15498 |
| NCBI GenInfo Identifier: | 13124807 |
| NCBI Gene ID: | 7409 |
| NCBI Accession: | P15498.4 |
| UniProt Secondary Accession: | P15498,Q15860, B4DVK9, M0QXX6, |
| UniProt Related Accession: | P15498 |
| Molecular Weight: | 845 |
| NCBI Full Name: | Proto-oncogene vav |
| NCBI Synonym Full Names: | vav 1 guanine nucleotide exchange factor |
| NCBI Official Symbol: | VAV1 |
| NCBI Official Synonym Symbols: | VAV |
| NCBI Protein Information: | proto-oncogene vav; vav 1 oncogene |
| UniProt Protein Name: | Proto-oncogene vav |
| Protein Family: | Proto-oncogene |
| UniProt Gene Name: | VAV1 |
| UniProt Entry Name: | VAV_HUMAN |
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