Description
Product Name: | Phospho-Tyk2-Y292 Rabbit pAb |
Product Code: | CABP0565 |
Size: | 20uL, 50uL, 100uL |
Synonyms: | TYK2, IMD35, JTK1 |
Applications: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | A synthetic phosphorylated peptide around Y292 of human Tyk2 (NP_003322.3). |
Applications: | WB |
Recommended Dilutions: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Immunogen: | A synthetic phosphorylated peptide around Y292 of human Tyk2 (NP_003322.3). |
Purification Method: | Affinity purification |
Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | PCYI R |
Gene ID: | 7297 |
Uniprot: | P29597 |
Calculated MW: | 133kDa |
Observed MW: | Refer to figures |
UniProt Protein Function: | Tyk2: a non-receptor tyrosine-protein kinase of the JakA family. Activated in signaling from the IL-2, gp130 and IFN families of receptors. Phosphorylates the interferon-alpha/beta receptor alpha chain. |
UniProt Protein Details: | Protein type:Protein kinase, TK; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; JakA family Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; cytoplasm; nucleus; cytosol Molecular Function:protein binding; growth hormone receptor binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; type 1 angiotensin receptor binding; ATP binding Biological Process: cell migration; cytokine and chemokine mediated signaling pathway; innate immune response; cell differentiation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation Disease: Immunodeficiency 35 |
NCBI Summary: | This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008] |
UniProt Code: | P29597 |
NCBI GenInfo Identifier: | 56405328 |
NCBI Gene ID: | 7297 |
NCBI Accession: | P29597.3 |
UniProt Secondary Accession: | P29597,Q6QB10, Q96CH0, |
UniProt Related Accession: | P29597 |
Molecular Weight: | 1187 |
NCBI Full Name: | Non-receptor tyrosine-protein kinase TYK2 |
NCBI Synonym Full Names: | tyrosine kinase 2 |
NCBI Official Symbol: | TYK2 |
NCBI Official Synonym Symbols: | JTK1; IMD35 |
NCBI Protein Information: | non-receptor tyrosine-protein kinase TYK2 |
UniProt Protein Name: | Non-receptor tyrosine-protein kinase TYK2 |
Protein Family: | Non-receptor tyrosine-protein kinase |
UniProt Gene Name: | TYK2 |
UniProt Entry Name: | TYK2_HUMAN |