Cell Biology Antibodies 16
Anti-Phospho-Tyk2-Y1054/1055 Antibody (CABP0543)
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- SKU:
- CABP0543
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Phospho-Tyk2-Y1054/1055 Antibody |
| Antibody SKU: | CABP0543 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around Y1054 & Y1055 of human Tyk2 (NP_003322.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Mouse |
| Positive Samples: | NIH/3T3 |
| Immunogen: | A synthetic phosphorylated peptide around Y1054 & Y1055 of human Tyk2 (NP_003322.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EYYR |
| Gene ID: | 7297 |
| Uniprot: | P29597 |
| Cellular Location: | |
| Calculated MW: | 133kDa |
| Observed MW: | 134KDa |
 | Western blot analysis of extracts of NIH/3T3 cells, using Phospho-Tyk2-Y1054/1055 Rabbit pAb (CABP0543) at 1:1000 dilution.NIH/3T3 cells were treated by IFN-a (100 ng/ml) at 37'C for 30 minutes after serum-starvation overnight. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s. |
| Synonyms: | TYK2, IMD35, JTK1 |
| Background: | This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. |
| UniProt Protein Function: | Tyk2: a non-receptor tyrosine-protein kinase of the JakA family. Activated in signaling from the IL-2, gp130 and IFN families of receptors. Phosphorylates the interferon-alpha/beta receptor alpha chain. |
| UniProt Protein Details: | Protein type:Protein kinase, TK; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; JakA family Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; cytoplasm; nucleus; cytosol Molecular Function:protein binding; growth hormone receptor binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; type 1 angiotensin receptor binding; ATP binding Biological Process: cell migration; cytokine and chemokine mediated signaling pathway; innate immune response; cell differentiation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation Disease: Immunodeficiency 35 |
| NCBI Summary: | This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P29597 |
| NCBI GenInfo Identifier: | 56405328 |
| NCBI Gene ID: | 7297 |
| NCBI Accession: | P29597.3 |
| UniProt Secondary Accession: | P29597,Q6QB10, Q96CH0, |
| UniProt Related Accession: | P29597 |
| Molecular Weight: | 1187 |
| NCBI Full Name: | Non-receptor tyrosine-protein kinase TYK2 |
| NCBI Synonym Full Names: | tyrosine kinase 2 |
| NCBI Official Symbol: | TYK2 |
| NCBI Official Synonym Symbols: | JTK1; IMD35 |
| NCBI Protein Information: | non-receptor tyrosine-protein kinase TYK2 |
| UniProt Protein Name: | Non-receptor tyrosine-protein kinase TYK2 |
| Protein Family: | Non-receptor tyrosine-protein kinase |
| UniProt Gene Name: | TYK2 |
| UniProt Entry Name: | TYK2_HUMAN |
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