| UniProt Protein Function: | MST2: a protein kinase of the STE20 family. Activated by apoptotic signals as well as other stress conditions. Full activation requires both phosphorylation and caspase-mediated cleavage. Following cleavage by caspase-3, undergoes irreversible autophosphorylation. Full-length is mainly unphosphorylated in the rat thymus and cultured cells, whereas caspase-3-cleaved MST2 in apoptotic cells is highly phosphorylated. |
| UniProt Protein Details: | Protein type:Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Autophagy; EC 2.7.11.1; STE group; STE20 family; MST subfamily Chromosomal Location of Human Ortholog: 8q22.2 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:protein dimerization activity; protein serine/threonine kinase activity; protein serine/threonine kinase activator activity; protein binding; magnesium ion binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity Biological Process: central nervous system development; positive regulation of protein binding; protein stabilization; positive regulation of apoptosis; apoptosis; positive regulation of JNK cascade; signal transduction; negative regulation of organ growth; protein amino acid phosphorylation; negative regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; positive regulation of fat cell differentiation; positive regulation of transcription factor activity; neural tube formation |
| NCBI Summary: | This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q13188 |
| NCBI GenInfo Identifier: | 46577700 |
| NCBI Gene ID: | 6788 |
| NCBI Accession: | Q13188.2 |
| UniProt Secondary Accession: | Q13188,Q15445, Q15801, Q96FM6, A8K722, B3KYA7, |
| UniProt Related Accession: | Q13188 |
| Molecular Weight: | 491 |
| NCBI Full Name: | Serine/threonine-protein kinase 3 |
| NCBI Synonym Full Names: | serine/threonine kinase 3 |
| NCBI Official Symbol: | STK3 |
| NCBI Official Synonym Symbols: | KRS1; MST2 |
| NCBI Protein Information: | serine/threonine-protein kinase 3; MST-2; STE20-like kinase MST2; mammalian STE20-like protein kinase 2; serine/threonine-protein kinase Krs-1; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog) |
| UniProt Protein Name: | Serine/threonine-protein kinase 3 |
| UniProt Synonym Protein Names: | Mammalian STE20-like protein kinase 2; MST-2; STE20-like kinase MST2; Serine/threonine-protein kinase Krs-1Cleaved into the following 2 chains:Serine/threonine-protein kinase 3 36kDa subunit; MST2/N; Serine/threonine-protein kinase 3 20kDa subunit; MST2/C |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | STK3 |
| UniProt Entry Name: | STK3_HUMAN |
