ChIP Antibodies
Anti-Phospho-STAT2-Y690 Antibody (CABP0284)
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- SKU:
- CABP0284
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-Phospho-STAT2-Y690 Antibody |
| Antibody SKU: | CABP0284 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around Y690 of human STAT2 (NP_005410.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NIH/3T3 |
| Immunogen: | A synthetic phosphorylated peptide around Y690 of human STAT2 (NP_005410.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RKYL K |
| Gene ID: | 6773 |
| Uniprot: | P52630 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 97kDa |
| Observed MW: | 113KDa |
 | Western blot analysis of extracts of various cell lines, using Anti-Phospho-STAT2-Y690 Antibody (CABP0284) at 1:1000 dilution.NIH/3T3 cells were treated by TNF-a (20 ng/mL) at 37'C for 30 minutes. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3min. |
| Synonyms: | STAT2, IMD44, ISGF-3, P113, STAT113 |
| Background: | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | STAT2: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Binds to the IFN-stimulated response element (ISRE) and to the Gas element. This multiprotein transcription factor is termed ISGF3. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q13.3 Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane Molecular Function:DNA binding; identical protein binding; protein binding; signal transducer activity; transcription factor activity Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; JAK-STAT cascade; positive regulation of defense response to virus by host; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction |
| NCBI Summary: | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
| UniProt Code: | P52630 |
| NCBI GenInfo Identifier: | 1711552 |
| NCBI Gene ID: | 6773 |
| NCBI Accession: | P52630.1 |
| UniProt Secondary Accession: | P52630,Q16430, Q16431, Q9UDL4, B4DLC7, G3V2M6, |
| UniProt Related Accession: | P52630 |
| Molecular Weight: | 97,457 Da |
| NCBI Full Name: | Signal transducer and activator of transcription 2 |
| NCBI Synonym Full Names: | signal transducer and activator of transcription 2 |
| NCBI Official Symbol: | STAT2 |
| NCBI Official Synonym Symbols: | P113; IMD44; ISGF-3; STAT113 |
| NCBI Protein Information: | signal transducer and activator of transcription 2 |
| UniProt Protein Name: | Signal transducer and activator of transcription 2 |
| UniProt Synonym Protein Names: | p113 |
| Protein Family: | Signal transducer and activator of transcription |
| UniProt Gene Name: | STAT2 |
| UniProt Entry Name: | STAT2_HUMAN |
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