Cell Biology Antibodies 14
Anti-Phospho-SMO-S616 Antibody (CABP0938)
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- SKU:
- CABP0938
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Phospho-SMO-S616 Antibody |
| Antibody SKU: | CABP0938 |
| Antibody Size: | 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around S616 of human SMO. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic phosphorylated peptide around S616 of human SMO. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6608 |
| Uniprot: | Q99835 |
| Cellular Location: | Cell projection, Membrane, Multi-pass membrane protein, cilium |
| Calculated MW: | 86kDa |
| Observed MW: | Refer to figures |
| Synonyms: | Gx, CRJS, SMOH, FZD11, SMO |
| Background: | The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. |
| UniProt Protein Function: | SMO: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. Belongs to the G-protein coupled receptor Fz/Smo family. |
| UniProt Protein Details: | Protein type:GPCR, Fz/Smo family; Receptor, GPCR; Membrane protein, multi-pass; Cell development/differentiation; Membrane protein, integral; Oncoprotein Chromosomal Location of Human Ortholog: 7q32.3 Cellular Component: caveola; Golgi apparatus; integral to membrane; intracellular membrane-bound organelle; plasma membrane Molecular Function:drug binding; G-protein coupled receptor activity; patched binding; protein binding; Wnt receptor activity; Wnt-protein binding Biological Process: activation of hh target transcription factor; forebrain morphogenesis; heart looping; midgut development; negative regulation of DNA binding; smoothened signaling pathway; ventral midline determination; Wnt receptor signaling pathway through beta-catenin |
| NCBI Summary: | The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010] |
| UniProt Code: | Q99835 |
| NCBI GenInfo Identifier: | 6226142 |
| NCBI Gene ID: | 6608 |
| NCBI Accession: | Q99835.1 |
| UniProt Secondary Accession: | Q99835,A4D1K5, |
| UniProt Related Accession: | Q99835 |
| Molecular Weight: | 86,397 Da |
| NCBI Full Name: | Smoothened homolog |
| NCBI Synonym Full Names: | smoothened, frizzled class receptor |
| NCBI Official Symbol: | SMO |
| NCBI Official Synonym Symbols: | Gx; SMOH; FZD11 |
| NCBI Protein Information: | smoothened homolog |
| UniProt Protein Name: | Smoothened homolog |
| UniProt Synonym Protein Names: | Protein Gx |
| Protein Family: | Smoothelin |
| UniProt Gene Name: | SMO |
| UniProt Entry Name: | SMO_HUMAN |
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