Cell Biology Antibodies 17
Anti-Phospho-RYR2-S2814 Antibody (CABP0624)
- SKU:
- CABP0624
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Phospho-RYR2-S2814 Antibody |
| Antibody SKU: | CABP0624 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S2815 of human RYR2 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S2815 of human RYR2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6262 |
| Uniprot: | Q92736 |
| Cellular Location: | Membrane, Multi-pass membrane protein, Sarcoplasmic reticulum membrane |
| Calculated MW: | 564kDa/565kDa |
| Observed MW: | Refer to Figures |
| Synonyms: | RYR2, ARVC2, ARVD2, RYR-2, RyR, VTSIP, RYR2 |
| Background: | This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. |
| UniProt Protein Function: | RYR2: ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described. |
| UniProt Protein Details: | Protein type:Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated; Transporter Chromosomal Location of Human Ortholog: 1q43 Cellular Component: sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; protein complex; membrane; sarcoplasmic reticulum; plasma membrane; Z disc Molecular Function:calcium-induced calcium release activity; calmodulin binding; identical protein binding; protein binding; enzyme binding; protein self-association; calcium-release channel activity; calcium channel activity; calcium ion binding; intracellular ligand-gated calcium channel activity; ryanodine-sensitive calcium-release channel activity Biological Process: positive regulation of sequestering of calcium ion; cytosolic calcium ion homeostasis; regulation of heart rate; calcium-mediated signaling; positive regulation of heart rate; response to redox state; Wnt receptor signaling pathway through beta-catenin; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; response to caffeine; cellular calcium ion homeostasis; BMP signaling pathway; calcium ion transport; release of sequestered calcium ion into cytosol; response to hypoxia; detection of calcium ion; transmembrane transport; cardiac muscle contraction Disease: Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy; Arrhythmogenic Right Ventricular Dysplasia, Familial, 2 |
| NCBI Summary: | This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92736 |
| NCBI GenInfo Identifier: | 308153558 |
| NCBI Gene ID: | 6262 |
| NCBI Accession: | Q92736.3 |
| UniProt Secondary Accession: | Q92736,Q15411, Q546N8, Q5T3P2, |
| UniProt Related Accession: | Q92736 |
| Molecular Weight: | 565kDa |
| NCBI Full Name: | Ryanodine receptor 2 |
| NCBI Synonym Full Names: | ryanodine receptor 2 (cardiac) |
| NCBI Official Symbol: | RYR2 |
| NCBI Official Synonym Symbols: | RyR; ARVC2; ARVD2; RYR-2; VTSIP |
| NCBI Protein Information: | ryanodine receptor 2; type 2 ryanodine receptor; islet-type ryanodine receptor; kidney-type ryanodine receptor; cardiac-type ryanodine receptor; cardiac muscle ryanodine receptor-calcium release channel |
| UniProt Protein Name: | Ryanodine receptor 2 |
| UniProt Synonym Protein Names: | Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor |
| Protein Family: | Ryanodine receptor |
| UniProt Gene Name: | RYR2 |
| UniProt Entry Name: | RYR2_HUMAN |
| Abd Alla et al. | BBLN triggers CAMK2D pathology in mice under cardiac pressure overload and potentially in unrepaired hearts with tetralogy of Fallot | Nature Cardiovascular Research 2023 | View Citation |
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