Anti-Phospho-RIPK1/RIP-S166 Antibody (CABP1230)

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SKU:
CABP1230
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
RIP
Synonyms:
RIP-1
Synonyms:
RIP1
Synonyms:
RIPK1

Description

Product Name:Phospho-RIPK1/RIP-S166 Rabbit pAb
Product Code:CABP1230
Size:50uL, 100uL
Synonyms:RIP, RIP-1, RIP1, RIPK1
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding S166 of human RIPK1/RIP
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HT-29, NIH/3T3
Immunogen:A phospho specific peptide corresponding to residues surrounding S166 of human RIPK1/RIP
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8737
Uniprot:Q8NFZ0
Observed MW:78kDa
UniProt Protein Function:FBXO18: DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction. Belongs to the helicase family. UvrD subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Helicase; EC 3.6.4.12 Chromosomal Location of Human Ortholog: 10p15.1 Cellular Component: chromatin; nucleus; SCF ubiquitin ligase complex Molecular Function: 3'-5' DNA helicase activity; DNA helicase activity; DNA translocase activity; double-stranded DNA binding; protein binding; single-stranded DNA binding Biological Process: cell death; DNA catabolic process, endonucleolytic; double-strand break repair via homologous recombination; positive regulation of protein amino acid phosphorylation; protein ubiquitination; replication fork processing; replication fork protection; response to DNA damage stimulus
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q8NFZ0
NCBI GenInfo Identifier:45476952
NCBI Gene ID:84893
NCBI Accession:Q8NFZ0.2
UniProt Secondary Accession:Q8NFZ0,Q5JVB0, Q5JVB1, Q7Z4Q6, Q7Z4R0, Q8N1P5, Q8N586 Q96E82, Q96K67, Q96SW7
UniProt Related Accession:Q8NFZ0
Molecular Weight:123,375 Da
NCBI Full Name:F-box DNA helicase 1
NCBI Synonym Full Names:F-box protein, helicase, 18
NCBI Official Symbol:FBXO18  
NCBI Official Synonym Symbols:FBH1; Fbx18; hFBH1  
NCBI Protein Information:F-box DNA helicase 1
UniProt Protein Name:F-box DNA helicase 1
UniProt Synonym Protein Names:F-box only protein 18
Protein Family:F-box DNA helicase
UniProt Gene Name:FBXO18  
UniProt Entry Name:FBH1_HUMAN
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