Anti-Phospho-RIP3-T231/S232 Antibody (CABP1260)
- SKU:
- CABP1260
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- R
- Synonyms:
- Rip3
- Synonyms:
- AW107945
- Synonyms:
- 2610528K09Rik
Description
| Product Name: | Phospho-RIP3-T231/S232 Rabbit pAb |
| Product Code: | CABP1260 |
| Size: | 50uL, 100uL |
| Synonyms: | R, Rip3, AW107945, 2610528K09Rik |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding T231/S232 of Mouse Ripk3. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | L929 |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding T231/S232 of Mouse Ripk3. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 56532 |
| Uniprot: | Q9QZL0 |
| Calculated MW: | 53kDa |
| Observed MW: | 53kDa |
| UniProt Protein Function: | Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9QZL0 |
| NCBI GenInfo Identifier: | 256017133 |
| NCBI Gene ID: | 56532 |
| NCBI Accession: | NP_064339.2 |
| UniProt Secondary Accession: | Q9QZL0,Q3U3Z9, Q8K2Y2, G3X8V8 |
| UniProt Related Accession: | Q9QZL0 |
| Molecular Weight: | 46-62 |
| NCBI Full Name: | receptor-interacting serine/threonine-protein kinase 3 isoform 1 |
| NCBI Synonym Full Names: | receptor-interacting serine-threonine kinase 3 |
| NCBI Official Symbol: | Ripk3 |
| NCBI Official Synonym Symbols: | Rip3; AW107945; 2610528K09Rik |
| NCBI Protein Information: | receptor-interacting serine/threonine-protein kinase 3 |
| UniProt Protein Name: | Receptor-interacting serine/threonine-protein kinase 3 |
| UniProt Synonym Protein Names: | RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3; mRIP3 |
| Protein Family: | Putative zinc metalloprotease |
| UniProt Gene Name: | Ripk3 |
| UniProt Entry Name: |
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