Immunology Antibodies 3
Anti-Phospho-RICTOR-T1135 pAb Antibody (CABP0869)
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- SKU:
- CABP0869
Description
| Antibody Name: | Anti-Phospho-RICTOR-T1135 Antibody |
| Antibody SKU: | CABP0869 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around T1135 of human RICTOR (NP_689969.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic phosphorylated peptide around T1135 of human RICTOR (NP_689969.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TLTE P |
| Gene ID: | 253260 |
| Uniprot: | Q6R327 |
| Cellular Location: | |
| Calculated MW: | 28kDa/192kDa/195kDa |
| Observed MW: |
| Synonyms: | RICTOR, AVO3, PIA, hAVO3 |
| Background: | RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008] |
| UniProt Protein Function: | RICTOR: a regulatory binding partner of the kinase mTOR. Part of a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Rictor interacts with Cullin1-Rbx1 to form an E3 ubiquitin ligase complex, and promotes ubiquitination and degradation of SGK1. Shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Ubiquitin conjugating system; Adaptor/scaffold Chromosomal Location of Human Ortholog: 5p13.1 Cellular Component: cytosol; TORC2 complex Molecular Function:enzyme activator activity; protein binding; protein kinase binding Biological Process: actin cytoskeleton reorganization; embryonic development; establishment and/or maintenance of actin cytoskeleton polarity; establishment of cell polarity; peptidyl-serine phosphorylation; phosphoinositide-mediated signaling; positive regulation of protein kinase B signaling cascade; positive regulation of TOR signaling pathway; regulation of actin cytoskeleton organization and biogenesis; regulation of phosphorylation; regulation of protein kinase B signaling cascade; T cell costimulation |
| NCBI Summary: | RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q6R327 |
| NCBI GenInfo Identifier: | 74710068 |
| NCBI Gene ID: | 253260 |
| NCBI Accession: | Q6R327.1 |
| UniProt Secondary Accession: | Q6R327,Q68DT5, Q86UB7, Q8N3A0, Q8NCM6, B2RNX0, B7ZMF7 |
| UniProt Related Accession: | Q6R327 |
| Molecular Weight: | 195,011 Da |
| NCBI Full Name: | Rapamycin-insensitive companion of mTOR |
| NCBI Synonym Full Names: | RPTOR independent companion of MTOR complex 2 |
| NCBI Official Symbol: | RICTOR |
| NCBI Official Synonym Symbols: | PIA; AVO3; hAVO3 |
| NCBI Protein Information: | rapamycin-insensitive companion of mTOR |
| UniProt Protein Name: | Rapamycin-insensitive companion of mTOR |
| UniProt Synonym Protein Names: | AVO3 homolog; hAVO3 |
| Protein Family: | Rapamycin-insensitive companion |
| UniProt Gene Name: | RICTOR |
| UniProt Entry Name: | RICTR_HUMAN |
Additional Information
Product Type: |
Antibody |
Applications: |
WB |
Reactivity: |
Human |
Host Species: |
Rabbit |
Isotype: |
IgG |
Research Area: |
Immunology |
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