Immunology Antibodies 3
Anti-Phospho-Raptor-Ser792 Antibody (CABP0928)
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- SKU:
- CABP0928
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-Phospho-Raptor-Ser792 Antibody |
| Antibody SKU: | CABP0928 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Ser792 of human RPTOR |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Ser792 of human RPTOR |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 57521 |
| Uniprot: | Q8N122 |
| Cellular Location: | Cytoplasm, Cytoplasmic granule, Lysosome |
| Calculated MW: | 43kDa/131kDa/149kDa |
| Observed MW: | Refer to figures |
 | Western blot - Phospho-Raptor-Ser792 Rabbit pAb (CABP0928) |
| Synonyms: | KOG1, Mip1, RPTOR |
| Background: | This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
| UniProt Protein Function: | Raptor: Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Interacts with MTOR. Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Binds directly to 4EBP1 and RPS6KB1 independently of its association with MTOR. Binds preferentially to poorly or non-phosphorylated forms of EIF4EBP1, and this binding is critical to the ability of MTOR to catalyze phosphorylation. Forms a complex with MTOR under both leucine-rich and -poor conditions. Interacts with ULK1 in a nutrient-dependent manner; the interaction is reduced during starvation. Interacts (when phosphorylated by AMPK) with 14-3-3 protein, leading to inhibit its activity. Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta. Belongs to the WD repeat RAPTOR family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; lysosomal membrane; lysosome; nucleoplasm Molecular Function:protein binding; protein binding, bridging; protein complex binding; protein kinase activator activity; protein kinase binding Biological Process: cell cycle arrest; cell growth; cellular response to nutrient levels; macroautophagy; positive regulation of TOR signaling pathway; positive regulation of transcription from RNA polymerase III promoter; regulation of cell size; TOR signaling pathway |
| NCBI Summary: | This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
| UniProt Code: | Q8N122 |
| NCBI GenInfo Identifier: | 46577501 |
| NCBI Gene ID: | 57521 |
| NCBI Accession: | Q8N122.1 |
| UniProt Secondary Accession: | Q8N122,Q8N4V9, Q8TB32, Q9P2P3, B2RN36, C6KEF2, F5H7J5 |
| UniProt Related Accession: | Q8N122 |
| Molecular Weight: | 131,515 Da |
| NCBI Full Name: | Regulatory-associated protein of mTOR |
| NCBI Synonym Full Names: | regulatory associated protein of MTOR complex 1 |
| NCBI Official Symbol: | RPTOR |
| NCBI Official Synonym Symbols: | KOG1; Mip1 |
| NCBI Protein Information: | regulatory-associated protein of mTOR |
| UniProt Protein Name: | Regulatory-associated protein of mTOR |
| UniProt Synonym Protein Names: | p150 target of rapamycin (TOR)-scaffold protein |
| Protein Family: | Regulatory-associated protein |
| UniProt Gene Name: | RPTOR |
| UniProt Entry Name: | RPTOR_HUMAN |
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