Cell Biology Antibodies 15
Anti-Phospho-Rac1/Cdc42-S71 Antibody (CABP1018)
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- SKU:
- CABP1018
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
Description
| Antibody Name: | Anti-Phospho-Rac1/Cdc42-S71 Antibody |
| Antibody SKU: | CABP1018 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S71 of human Rac1/Cdc42 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-431 |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S71 of human Rac1/Cdc42 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 998/5879 |
| Uniprot: | P60953/P63000 |
| Cellular Location: | |
| Calculated MW: | 24kDa |
| Observed MW: | 24KDa |
 | Western blot - Phospho-Rac1/Cdc42-S71 Rabbit mAb (CABP1018) |
| Synonyms: | CDC42Hs, G25K, TKS |
| Background: | The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013] |
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