Cell Biology Antibodies 16
Anti-Phospho-PTPRA-Y789 pAb Antibody (CABP0814)
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- SKU:
- CABP0814
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Phospho-PTPRA-Y789 Antibody |
| Antibody SKU: | CABP0814 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Y789 of human PTPRA |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | C2C12, PC-12 |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Y789 of human PTPRA |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5786 |
| Uniprot: | P18433 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 89kDa/90kDa |
| Observed MW: | 145kDa |
 | Western blot analysis of extracts of C2C12 and PC-12 cells, using Phospho-PTPRA-Y789 antibody (CABP0814) at 1:1000 dilution. C2C12 cell lysate were treated by CIP (20ul CIP for each 400ul cell lysate) at 37'C for 1 hour .PC-12 cell lysate were treated by CIP (20ul CIP for each 400ul cell lysate) at 37'C for 1 hour . Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
| Synonyms: | PTPRA, HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, R-PTP-alpha, RPTPA |
| Background: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. |
| UniProt Protein Function: | PTPRA: a receptor protein tyrosine phosphatase (PTP). Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. Dephosphorylates and activates Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Four alternatively spliced isoforms have been reported. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis; EC 3.1.3.48 Chromosomal Location of Human Ortholog: 20p13 Cellular Component: integral to plasma membrane; plasma membrane; receptor complex Molecular Function:protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity Biological Process: axon guidance; insulin receptor signaling pathway; protein amino acid phosphorylation |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P18433 |
| NCBI GenInfo Identifier: | 126467 |
| NCBI Gene ID: | 5786 |
| NCBI Accession: | P18433.2 |
| UniProt Secondary Accession: | P18433,Q14513, Q7Z2I2, Q96TD9, A8K2G8, D3DVX5, |
| UniProt Related Accession: | P18433 |
| Molecular Weight: | 802 |
| NCBI Full Name: | Receptor-type tyrosine-protein phosphatase alpha |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type, A |
| NCBI Official Symbol: | PTPRA |
| NCBI Official Synonym Symbols: | LRP; HLPR; PTPA; HEPTP; HPTPA; RPTPA; PTPRL2; HPTPalpha; R-PTP-alpha |
| NCBI Protein Information: | receptor-type tyrosine-protein phosphatase alpha; PTPase-alpha; PTPLCA-related phosphatase; tyrosine phosphatase alpha; protein-tyrosine phosphatase alpha; protein tyrosine phosphatase, receptor type, alpha polypeptide; Leukocyte common antigen-related peptide (protein tyrosine phosphate) |
| UniProt Protein Name: | Receptor-type tyrosine-protein phosphatase alpha |
| Protein Family: | Receptor-type tyrosine-protein phosphatase |
| UniProt Gene Name: | PTPRA |
| UniProt Entry Name: | PTPRA_HUMAN |
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