Description
Product Name: | Phospho-PLN-S16/T17 Rabbit pAb |
Product Code: | CABP0956 |
Size: | 20uL, 50uL, 100uL |
Synonyms: | CMD1P, CMH18, PLB, PLN |
Applications: | WB |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthetic phosphorylated peptide around of human Phospho-PLN-S16/T17. |
Applications: | WB |
Recommended Dilutions: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | HeLa, C6 |
Immunogen: | A synthetic phosphorylated peptide around of human Phospho-PLN-S16/T17. |
Purification Method: | Affinity purification |
Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 5350 |
Uniprot: | P26678 |
Calculated MW: | 6kDa |
Observed MW: | 13kDa/17KDa |
UniProt Protein Function: | PLB: a heart protein postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum. A major substrate for the cAMP-dependent protein kinase. An inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. A key regulator of cardiac diastolic function. Mutations are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Inhibitor Chromosomal Location of Human Ortholog: 6q22.1 Cellular Component: endoplasmic reticulum; membrane; mitochondrion; perinuclear region of cytoplasm; sarcoplasmic reticulum membrane Molecular Function:ATPase binding; ATPase inhibitor activity; enzyme inhibitor activity; identical protein binding; protein binding Biological Process: cytosolic calcium ion homeostasis; negative regulation of ATPase activity; negative regulation of calcium ion transport; negative regulation of catalytic activity; negative regulation of heart rate; regulation of calcium ion transport; regulation of heart contraction; regulation of the force of heart contraction Disease: Cardiomyopathy, Dilated, 1p; Cardiomyopathy, Familial Hypertrophic, 18 |
NCBI Summary: | The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016] |
UniProt Code: | P26678 |
NCBI GenInfo Identifier: | 130774 |
NCBI Gene ID: | 5350 |
NCBI Accession: | P26678.1 |
UniProt Secondary Accession: | P26678,P61016, P61015, P61013, P61014, A4IFH6, |
UniProt Related Accession: | P26678 |
Molecular Weight: | 6,109 Da |
NCBI Full Name: | Cardiac phospholamban |
NCBI Synonym Full Names: | phospholamban |
NCBI Official Symbol: | PLN |
NCBI Official Synonym Symbols: | PLB; CMD1P; CMH18 |
NCBI Protein Information: | cardiac phospholamban |
UniProt Protein Name: | Cardiac phospholamban |
Protein Family: | Cardiac phospholamban |
UniProt Gene Name: | PLN |
UniProt Entry Name: | PPLA_HUMAN |