Cell Biology Antibodies 14

Anti-Phospho-PKA R2-S99 Antibody (CABP1034)

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SKU:
CABP1034
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-Phospho-PKA R2-S99 Antibody
Antibody SKU:CABP1034
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding S99 of human PKA R2
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:293T, C6
Immunogen:A phospho specific peptide corresponding to residues surrounding S99 of human PKA R2
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5576
Uniprot:P13861
Cellular Location:
Calculated MW:51kDa
Observed MW:51KDa
Anti-Phospho-PKA R2-S99 Antibody (CABP1034)Western blot - Phospho-PKA R2-S99 Rabbit mAb (CABP1034)
Synonyms:PKR2, PRKAR2
Background:cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]
UniProt Protein Function:PKAR2A: a regulatory subunit of cAMP-regulated protein kinase. The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
UniProt Protein Details:

Protein type:Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 3p21.3-p21.2

Cellular Component: centrosome; focal adhesion; membrane; cytoplasm; plasma membrane; cytosol; AMP-activated protein kinase complex; cAMP-dependent protein kinase complex

Molecular Function:protein binding; cAMP-dependent protein kinase inhibitor activity; ubiquitin protein ligase binding; cAMP-dependent protein kinase regulator activity; cAMP binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; phospholipase C activation; water transport; activation of protein kinase A; energy reserve metabolic process; innate immune response; renal water homeostasis; blood coagulation; signal transduction; regulation of insulin secretion; transmembrane transport

NCBI Summary:cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]
UniProt Code:P13861
NCBI GenInfo Identifier:125198
NCBI Gene ID:5576
NCBI Accession:P13861.2
UniProt Secondary Accession:P13861,Q16823,
UniProt Related Accession:P13861
Molecular Weight:45,518 Da
NCBI Full Name:cAMP-dependent protein kinase type II-alpha regulatory subunit
NCBI Synonym Full Names:protein kinase, cAMP-dependent, regulatory, type II, alpha
NCBI Official Symbol:PRKAR2A  
NCBI Official Synonym Symbols:PKR2; PRKAR2  
NCBI Protein Information:cAMP-dependent protein kinase type II-alpha regulatory subunit; protein kinase A, RII-alpha subunit; cAMP-dependent protein kinase regulatory subunit RII alpha
UniProt Protein Name:cAMP-dependent protein kinase type II-alpha regulatory subunit
Protein Family:CD99 antigen
UniProt Gene Name:PRKAR2A  
UniProt Entry Name:KAP2_HUMAN
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