| UniProt Protein Function: | NPM1: a nucleolar protein associated with nucleolar ribonucleoprotein structures and that binds single-stranded nucleic acids. Is a major component of template activating factor (TAF)-III. It plays a role in controlling centrosome duplication, and may function in the assembly and/or transport of the ribosome. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Translation; RNA-binding; Nucleolus; Oncoprotein Chromosomal Location of Human Ortholog: 5q35.1 Cellular Component: centrosome; cytoplasm; cytosol; focal adhesion; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex; spindle pole centrosome Molecular Function:histone binding; NF-kappaB binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; protein kinase inhibitor activity; ribosomal large subunit binding; ribosomal small subunit binding; RNA binding; Tat protein binding; transcription coactivator activity; unfolded protein binding Biological Process: activation of NF-kappaB transcription factor; cell aging; centrosome cycle; DNA repair; DNA replication-independent nucleosome assembly at centromere; intracellular protein transport; negative regulation of apoptosis; negative regulation of cell proliferation; nucleocytoplasmic transport; nucleosome assembly; positive regulation of cell proliferation; positive regulation of transcription, DNA-dependent; positive regulation of translation; protein localization; protein oligomerization; regulation of centriole replication; regulation of endodeoxyribonuclease activity; response to stress; ribosome assembly; signal transduction; viral reproduction |
| NCBI Summary: | This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009] |
| UniProt Code: | P06748 |
| NCBI GenInfo Identifier: | 114762 |
| NCBI Gene ID: | 4869 |
| NCBI Accession: | P06748.2 |
| UniProt Secondary Accession: | P06748,P08693, Q12826, Q13440, Q13441, Q14115, Q5EU94 Q5EU95, Q5EU96, A8K3N7, B5BU00, D3DQL6, |
| UniProt Related Accession: | P06748 |
| Molecular Weight: | 28,400 Da |
| NCBI Full Name: | Nucleophosmin |
| NCBI Synonym Full Names: | nucleophosmin (nucleolar phosphoprotein B23, numatrin) |
| NCBI Official Symbol: | NPM1 |
| NCBI Official Synonym Symbols: | B23; NPM |
| NCBI Protein Information: | nucleophosmin |
| UniProt Protein Name: | Nucleophosmin |
| UniProt Synonym Protein Names: | Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin |
| Protein Family: | Nucleophosmin |
| UniProt Gene Name: | NPM1 |
| UniProt Entry Name: | NPM_HUMAN |
