Description
| Antibody Name: | Anti-Phospho-NAK/TBK1-S172 Antibody |
| Antibody SKU: | CABP1026 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S172 of human NAK/TBK1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, NIH/3T3 |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S172 of human NAK/TBK1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 29110 |
| Uniprot: | Q9UHD2 |
| Cellular Location: | |
| Calculated MW: | 84kDa |
| Observed MW: | 84KDa |
 | Western blot - Phospho-NAK/TBK1-S172 Rabbit mAb (CABP1026) |
| Synonyms: | FTDALS4, NAK, T2K |
| Background: | The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010] |
| UniProt Protein Function: | TBK1: a protein kinase of the IKK family. Can mediate NFkB activation in response to certain growth factors. Forms a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. |
| UniProt Protein Details: | Protein type:Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Other group; IKK family Chromosomal Location of Human Ortholog: 12q14.1 Cellular Component: cytoplasm; endosome membrane; cytosol Molecular Function:protein serine/threonine kinase activity; protein binding; nucleic acid binding; phosphoprotein binding; ATP binding; protein kinase activity Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; MyD88-independent toll-like receptor signaling pathway; response to virus; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; positive regulation of peptidyl-serine phosphorylation; defense response to Gram-positive bacterium; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon type I production; positive regulation of interferon-beta production; toll-like receptor signaling pathway; interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; negative regulation of interferon type I production; toll-like receptor 4 signaling pathway; defense response to virus; positive regulation of interferon-alpha production Disease: Frontotemporal Dementia And/or Amyotrophic Lateral Sclerosis 4 |
| NCBI Summary: | The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010] |
| UniProt Code: | Q9UHD2 |
| NCBI GenInfo Identifier: | 74761953 |
| NCBI Gene ID: | 29110 |
| NCBI Accession: | Q9UHD2.1 |
| UniProt Secondary Accession: | Q9UHD2,Q8IYV3, Q9NUJ5, A8K4S4, |
| UniProt Related Accession: | Q9UHD2 |
| Molecular Weight: | 83,642 Da |
| NCBI Full Name: | Serine/threonine-protein kinase TBK1 |
| NCBI Synonym Full Names: | TANK-binding kinase 1 |
| NCBI Official Symbol: | TBK1Â Â |
| NCBI Official Synonym Symbols: | NAK; T2KÂ Â |
| NCBI Protein Information: | serine/threonine-protein kinase TBK1; NF-kB-activating kinase; NF-kappa-B-activating kinase |
| UniProt Protein Name: | Serine/threonine-protein kinase TBK1 |
| UniProt Synonym Protein Names: | NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | TBK1Â Â |
| UniProt Entry Name: | TBK1_HUMAN |
