Signal Transduction Antibodies 3
Anti-Phospho-Na+/K+-ATPase-S16 Antibody (CABP1065)
- SKU:
- CABP1065
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Antibody Name: | Anti-Phospho-Na+/K+-ATPase-S16 Antibody |
Antibody SKU: | CABP1065 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A phospho specific peptide corresponding to residues surrounding S16 of human Na+/K+-ATPase. |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | 293T |
Immunogen: | A phospho specific peptide corresponding to residues surrounding S16 of human Na+/K+-ATPase. |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 476 |
Uniprot: | P05023 |
Cellular Location: | Cell membrane, Melanosome, Multi-pass membrane protein |
Calculated MW: | 112kDa |
Observed MW: | 112kDa |
Synonyms: | ATP1A1, ATPase Na+/K+ transporting subunit alpha 1, ATP1A, CMT2DD, HOMGSMR2 |
Background: | The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | ATP1A1: the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na and K ions across the plasma membrane. This action creates the electrochemical gradient of Na and K, providing the energy for active transport of various nutrients. Two splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: endoplasmic reticulum; Golgi apparatus; integral to membrane; membrane; plasma membrane; protein complex; sarcolemma; sodium:potassium-exchanging ATPase complex Molecular Function:ATP binding; chaperone binding; potassium ion binding; protein binding; sodium ion binding; sodium:potassium-exchanging ATPase activity Biological Process: cellular potassium ion homeostasis; cellular sodium ion homeostasis; potassium ion import; regulation of sodium ion transport |
NCBI Summary: | The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
UniProt Code: | P05023 |
NCBI GenInfo Identifier: | 114374 |
NCBI Gene ID: | 476 |
NCBI Accession: | P05023.1 |
UniProt Secondary Accession: | P05023,Q16689, Q6LDM4, Q9UCN1, Q9UJ20, Q9UJ21, B2RBR6 B7Z2T5, B7Z3U6, F5H3A1, |
UniProt Related Accession: | P05023 |
Molecular Weight: | 113kDa |
NCBI Full Name: | Sodium/potassium-transporting ATPase subunit alpha-1 |
NCBI Synonym Full Names: | ATPase Na+/K+ transporting subunit alpha 1 |
NCBI Official Symbol: | ATP1A1 |
NCBI Protein Information: | sodium/potassium-transporting ATPase subunit alpha-1 |
UniProt Protein Name: | Sodium/potassium-transporting ATPase subunit alpha-1 |
UniProt Synonym Protein Names: | Sodium pump subunit alpha-1 |
Protein Family: | Sodium/potassium-transporting ATPase |
UniProt Gene Name: | ATP1A1 |