Cell Biology Antibodies 16
Anti-Phospho-MYL9-S19 pAb Antibody (CABP0872)
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- SKU:
- CABP0872
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Phospho-MYL9-S19 Antibody |
| Antibody SKU: | CABP0872 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around S19 of human MYL9 (NP_006088.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | C6 |
| Immunogen: | A synthetic phosphorylated peptide around S19 of human MYL9 (NP_006088.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RATS N |
| Gene ID: | 10398 |
| Uniprot: | P24844 |
| Cellular Location: | |
| Calculated MW: | 13kDa/19kDa |
| Observed MW: | 19kDa |
 | Western blot analysis of extracts of C6 cells, using Phospho-MYL9-S19 antibody (CABP0872) at 1:1000 dilution. C6 cells were treated by CIP(20uL/400ul) at 37'C for 1 hour. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
| Synonyms: | MYL9, LC20, MLC-2C, MLC2, MRLC1, MYRL2 |
| Background: | Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | MRLC1: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. Myosin is an hexamer of 2 heavy chains and 4 light chains. Smooth muscle tissues and in some, but not all, nonmuscle cells. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Contractile; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 20q11.23 Cellular Component: cytosol; muscle myosin complex; stress fiber; Z disc Molecular Function:calcium ion binding; myosin heavy chain binding; structural constituent of muscle Biological Process: axon guidance; ephrin receptor signaling pathway; muscle contraction; regulation of muscle contraction; small GTPase mediated signal transduction |
| NCBI Summary: | Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P24844 |
| NCBI GenInfo Identifier: | 20141521 |
| NCBI Gene ID: | 10398 |
| NCBI Accession: | P24844.4 |
| UniProt Secondary Accession: | P24844,Q9BQL9, Q9BUF9, Q9H136, E1P5T6, |
| UniProt Related Accession: | P24844 |
| Molecular Weight: | 13,866 Da |
| NCBI Full Name: | Myosin regulatory light polypeptide 9 |
| NCBI Synonym Full Names: | myosin light chain 9 |
| NCBI Official Symbol: | MYL9 |
| NCBI Official Synonym Symbols: | LC20; MLC2; MRLC1; MYRL2; MLC-2C |
| NCBI Protein Information: | myosin regulatory light polypeptide 9 |
| UniProt Protein Name: | Myosin regulatory light polypeptide 9 |
| UniProt Synonym Protein Names: | 20 kDa myosin light chain; LC20; MLC-2C; Myosin RLC; Myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 9; Myosin regulatory light chain MRLC1 |
| Protein Family: | Myosin regulatory light polypeptide |
| UniProt Gene Name: | MYL9 |
| UniProt Entry Name: | MYL9_HUMAN |
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