Cell Death Antibodies 2
Anti-Phospho-MST1/STK4-T387 Antibody (CABP0906)
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- SKU:
- CABP0906
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-Phospho-MST1/STK4-T387 Antibody |
| Antibody SKU: | CABP0906 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding T387 of human MST1/STK4. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NIH/3T3, C6 |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding T387 of human MST1/STK4. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6789 |
| Uniprot: | Q13043 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 59kDa |
| Observed MW: | 59kDa |
 | Western blot - Phospho-MST1/STK4-T387 Rabbit pAb (CABP0906) |
| Synonyms: | KRS2, MST1, YSK3, STK4 |
| Background: | The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. |
| NCBI Summary: | The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13043 |
| NCBI GenInfo Identifier: | 13124559 |
| NCBI Gene ID: | 6789 |
| NCBI Accession: | Q13043.2 |
| UniProt Secondary Accession: | Q13043,Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4 B2RCR8, |
| UniProt Related Accession: | Q13043 |
| Molecular Weight: | 52,335 Da |
| NCBI Full Name: | Serine/threonine-protein kinase 4 |
| NCBI Synonym Full Names: | serine/threonine kinase 4 |
| NCBI Official Symbol: | STK4 |
| NCBI Official Synonym Symbols: | KRS2; MST1; YSK3 |
| NCBI Protein Information: | serine/threonine-protein kinase 4 |
| UniProt Protein Name: | Serine/threonine-protein kinase 4 |
| UniProt Synonym Protein Names: | Mammalian STE20-like protein kinase 1; MST-1 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | STK4 |
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