Description
| Product Name: | Phospho-MLLT4-S1718 Rabbit pAb |
| Product Code: | CABP1238 |
| Size: | 50uL, 100uL |
| Synonyms: | AF6, MLL-AF6, MLLT4, l-afadin |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around S1718 of human MLLT4 (NP_001193937.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | A synthetic phosphorylated peptide around S1718 of human MLLT4 (NP_001193937.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4301 |
| Uniprot: | P55196 |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | Afadin: plays a role in adhesion by participating, along with E-cadherin and catenin, in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Essential for the association of nectin and E-cadherin. Contains 1 forkhead-associated (FHA) domain, a phosphopeptide recognition domain; 1 dilute (DIL) domain, a myosin-like domain which may play a functional role in cellular processes or vectorial vesicle transport; 1 PDZ domain, which frequently binds the carboxyl-terminal sequences of proteins or phosphatidylinositol 4,5-bisphosphate in the plasma membrane; and 2 RA domains, which are associated with RasGTP effector activity. Five alternatively spliced isoforms have been described. Isoform 2 does not interact with F-actin. Protein type: Oncoprotein; Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 6q27 Cellular Component: nucleoplasm; cell-cell adherens junction; apical part of cell; cytoplasm; plasma membrane; intercellular junction; cytosol; cell junction Molecular Function: protein C-terminus binding; protein binding; Ras GTPase binding; cell adhesion molecule binding Biological Process: intercellular junction assembly and maintenance; cell-cell signaling; cell adhesion; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011] |
| UniProt Code: | P55196 |
| NCBI GenInfo Identifier: | 288558835 |
| NCBI Gene ID: | 4301 |
| NCBI Accession: | P55196.3 |
| UniProt Secondary Accession: | P55196,O75087, O75088, O75089, Q59FP0, Q5TIG6, Q5TIG7 Q9NSN7, Q9NU92 |
| UniProt Related Accession: | P55196 |
| Molecular Weight: | 1824 |
| NCBI Full Name: | Afadin |
| NCBI Synonym Full Names: | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 |
| NCBI Official Symbol: | MLLT4Â Â |
| NCBI Official Synonym Symbols: | AF6Â Â |
| NCBI Protein Information: | afadin; protein AF-6; ALL1-fused gene from chromosome 6 protein |
| UniProt Protein Name: | Afadin |
| UniProt Synonym Protein Names: | ALL1-fused gene from chromosome 6 protein; Protein AF-6 |
| Protein Family: | Afadin |
| UniProt Gene Name: | MLLT4Â Â |
| UniProt Entry Name: | AFAD_HUMAN |
