Description
Product Name: | Phospho-MLKL-S441 Rabbit pAb |
Product Code: | CABP1174 |
Size: | 20uL, 50uL, 100uL |
Synonyms: | MLKL, hMLKL, mixed lineage kinase domain-like protein |
Applications: | WB |
Reactivity: | Human, Rat |
Host Species: | Rabbit |
Immunogen: | A phospho synthetic peptide corresponding to residues surrounding S441 of Mouse MLKL. |
Applications: | WB |
Recommended Dilutions: | WB 1:500 - 1:2000 |
Reactivity: | Human, Rat |
Positive Samples: | C6 |
Immunogen: | A phospho synthetic peptide corresponding to residues surrounding S441 of Mouse MLKL. |
Purification Method: | Affinity purification |
Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 74568 |
Uniprot: | Q9D2Y4 |
Cellular Location: | Cell membrane, Cytoplasm |
Calculated MW: | 53kDa/54kDa |
Observed MW: | 54KDa |
UniProt Protein Function: | MLKL: Belongs to the protein kinase superfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; TKL-Unique family Cellular Component: membrane; cytoplasm; plasma membrane Molecular Function: transferase activity, transferring phosphorus-containing groups; protein complex binding; nucleotide binding; protein kinase binding; ATP binding; protein kinase activity Biological Process: programmed cell death; protein amino acid phosphorylation |
UniProt Protein Details: | |
NCBI Summary: | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015] |
UniProt Code: | Q9D2Y4 |
NCBI GenInfo Identifier: | 81916976 |
NCBI Gene ID: | 74568 |
NCBI Accession: | Q9D2Y4.1 |
UniProt Secondary Accession: | Q9D2Y4,Q8CIJ5 |
UniProt Related Accession: | Q9D2Y4 |
Molecular Weight: | 54kDa |
NCBI Full Name: | Mixed lineage kinase domain-like protein |
NCBI Synonym Full Names: | mixed lineage kinase domain-like |
NCBI Official Symbol: | Mlkl |
NCBI Official Synonym Symbols: | 9130019I15Rik |
NCBI Protein Information: | mixed lineage kinase domain-like protein; mlkl |
UniProt Protein Name: | Mixed lineage kinase domain-like protein |
UniProt Synonym Protein Names: | |
Protein Family: | Mixed lineage kinase domain-like protein |
UniProt Gene Name: | Mlkl |
UniProt Entry Name: | MLKL_MOUSE |