| UniProt Protein Function: | MAPKAPK2: a member of the MAPKAPK family of protein kinases. It is phosphorylated and activated by p38 in response to cytokines, stress and chemotactic factors.MAPKAPK-2 is apparently a direct target of p38 MAPK. HSP27 is one of its in vivo substrates. Two transcript variants encoding two different isoforms have been described. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, CAMK; CAMK group; MAPKAPK family; MAPKAPK subfamily Chromosomal Location of Human Ortholog: 1q32 Cellular Component: centrosome; cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity; signal transducer activity Biological Process: activation of MAPK activity; G2/M transition DNA damage checkpoint; inflammatory response; inner ear development; leukotriene metabolic process; MAPKKK cascade; peptidyl-serine phosphorylation; positive regulation of tumor necrosis factor biosynthetic process; protein amino acid autophosphorylation; protein amino acid phosphorylation; Ras protein signal transduction; regulation of interleukin-6 production; regulation of mRNA stability; regulation of tumor necrosis factor production; response to cytokine stimulus; response to DNA damage stimulus; response to lipopolysaccharide; response to stress; toll-like receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49137 |
| NCBI GenInfo Identifier: | 1346538 |
| NCBI Gene ID: | 9261 |
| NCBI Accession: | P49137.1 |
| UniProt Secondary Accession: | P49137,Q5SY30, Q5SY41, Q8IYD6, |
| UniProt Related Accession: | P49137 |
| Molecular Weight: | 42,203 Da |
| NCBI Full Name: | MAP kinase-activated protein kinase 2 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase-activated protein kinase 2 |
| NCBI Official Symbol: | MAPKAPK2 |
| NCBI Official Synonym Symbols: | MK2; MK-2; MAPKAP-K2 |
| NCBI Protein Information: | MAP kinase-activated protein kinase 2 |
| UniProt Protein Name: | MAP kinase-activated protein kinase 2 |
| UniProt Gene Name: | MAPKAPK2 |
| UniProt Entry Name: | MAPK2_HUMAN |
