Cell Death Antibodies 2
Anti-Phospho-MAPK14-T180/Y182 Antibody (CABP0526)
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- SKU:
- CABP0526
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-Phospho-MAPK14-T180/Y182 Antibody |
| Antibody SKU: | CABP0526 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around T180 & Y182 of human p38 MAPK (NP_620581.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293, HeLa |
| Immunogen: | A synthetic phosphorylated peptide around T180 & Y182 of human p38 MAPK (NP_620581.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTGY V |
| Gene ID: | 5600/6300/5603/1432 |
| Uniprot: | Q15759/P53778/O15264/Q16539 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 29kDa/34kDa/35kDa/41kDa |
| Observed MW: | 41kDa |
 | Western blot analysis of extracts of HeLa cells, using Phospho-p38 MAPK-T180/Y182 antibody (CABP0526). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. |
 | Immunofluorescence analysis of mouse brain using Phospho-p38 MAPK-T180/Y182 antibody (CABP0526) at dilution of 1:100. Blue: DAPI for nuclear staining. |
| Synonyms: | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA, p38 MAPK |
| Background: | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
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