Cell Death Antibodies 2
Anti-Phospho-MAP3K7-T187 pAb Antibody (CABP0811)
- SKU:
- CABP0811
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-Phospho-MAP3K7-T187 Antibody |
| Antibody SKU: | CABP0811 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around T187 of human TAK1 (NP_003179.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | A synthetic phosphorylated peptide around T187 of human TAK1 (NP_003179.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HMTN N |
| Gene ID: | 6885 |
| Uniprot: | O43318 |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein |
| Calculated MW: | 53kDa/56kDa/64kDa/67kDa |
| Observed MW: | Refer to figures |
| Synonyms: | CSCF, FMD2, MEKK7, TAK1, TGF1a, MAP3K7 |
| Background: | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| UniProt Protein Function: | TAK1: a protein kinase of the MLK family. Mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. Also activates MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced isoforms have been reported. Three splice variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, TKL; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; TAK1 subfamily Chromosomal Location of Human Ortholog: 6q15 Cellular Component: nucleoplasm; cytoplasm; plasma membrane; endosome membrane; IkappaB kinase complex; nucleus; cytosol Molecular Function:MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP binding; protein kinase activity Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK activity; activation of MAPKK activity; apoptosis; activation of MAPK activity; stress-activated MAPK cascade; positive regulation of T cell cytokine production; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; transforming growth factor beta receptor signaling pathway; JNK cascade; angiogenesis; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-2 production; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; positive regulation of T cell activation; I-kappaB phosphorylation; neural tube formation |
| NCBI Summary: | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43318 |
| NCBI GenInfo Identifier: | 12643557 |
| NCBI Gene ID: | 6885 |
| NCBI Accession: | O43318.1 |
| UniProt Secondary Accession: | O43318,O43317, O43319, Q5TDN2, Q5TDN3, Q5TDT7, Q9NTR3 Q9NZ70, B2RE27, E1P523, |
| UniProt Related Accession: | O43318 |
| Molecular Weight: | 67,196 Da |
| NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 7 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 7 |
| NCBI Official Symbol: | MAP3K7 |
| NCBI Official Synonym Symbols: | TAK1; MEKK7; TGF1a |
| NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 7; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor-beta-activated kinase 1 |
| UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 7 |
| UniProt Synonym Protein Names: | Transforming growth factor-beta-activated kinase 1 |
| Protein Family: | Mitogen-activated protein kinase kinase kinase |
| UniProt Gene Name: | MAP3K7 |
| UniProt Entry Name: | M3K7_HUMAN |
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