Cell Biology Antibodies 16
Anti-Phospho-MAP2K6-S207/MAP2K3-S189 Antibody (CABP0081)
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- SKU:
- CABP0081
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Phospho-MAP2K6-S207/MAP2K3-S189 Antibody |
| Antibody SKU: | CABP0081 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around S207 of human MAP2K6 (NP_002749.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60 |
| Immunogen: | A synthetic phosphorylated peptide around S207 of human MAP2K6 (NP_002749.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VDSV A |
| Gene ID: | 5606/5608 |
| Uniprot: | P46734/P52564 |
| Cellular Location: | |
| Calculated MW: | 36kDa/39kDa/31kDa/37kDa |
| Observed MW: | 39kDa |
 | Western blot analysis of extracts of HL60 cell lines, using Phospho-MAP2K6-S207/MAP2K3-S189 antibody (CABP0081). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. |
 | Immunofluorescence analysis of U2OS cells using Phospho-MAP2K6-S207/MAP2K3-S189 antibody (CABP0081). Blue: DAPI for nuclear staining. |
| Synonyms: | MAP2K3/MAP2K6 |
| Background: | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] |
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