Cell Biology Antibodies 16
Anti-Phospho-KSR1-S392 Antibody (CABP0487)
- SKU:
- CABP0487
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Phospho-KSR1-S392 Antibody |
| Antibody SKU: | CABP0487 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S392 of human KSR1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S392 of human KSR1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8844 |
| Uniprot: | Q8IVT5 |
| Cellular Location: | Cytoplasm, Endoplasmic reticulum membrane, Membrane, Peripheral membrane protein |
| Calculated MW: | 84kDa/87kDa/97kDa/102kDa |
| Observed MW: | Refer to figures |
| Synonyms: | KSR1, KSR, RSU2 |
| Background: | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). |
| UniProt Protein Function: | KSR: a serine/threonine kinase of the Raf family with no demonstrated kinase activity. A location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. Interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization. In unstimulated cells, the phosphorylated form is bound to a 14-3-3 protein and sequestered in the cytoplasm. Translocates from the cytoplasm to the cell periphery following TNF treatment. When Bad is available, ceramide signaling through the Ras/Raf cascade can lead to apoptosis. Three alternatively-spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; RAF family Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; protein complex Molecular Function:ATP binding; MAP-kinase scaffold activity; metal ion binding; mitogen-activated protein kinase kinase binding; protein binding; protein C-terminus binding; protein kinase activity Biological Process: activation of MAPKK activity; axon guidance; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway |
| UniProt Code: | Q8IVT5 |
| NCBI GenInfo Identifier: | 677286751 |
| NCBI Gene ID: | 8844 |
| NCBI Accession: | Q8IVT5.3 |
| UniProt Secondary Accession: | Q8IVT5,Q13476, F8WEA9, H7BYU0, |
| UniProt Related Accession: | Q8IVT5 |
| Molecular Weight: | 84,697 Da |
| NCBI Full Name: | Kinase suppressor of Ras 1 |
| NCBI Synonym Full Names: | kinase suppressor of ras 1 |
| NCBI Official Symbol: | KSR1 |
| NCBI Official Synonym Symbols: | KSR; RSU2 |
| NCBI Protein Information: | kinase suppressor of Ras 1 |
| UniProt Protein Name: | Kinase suppressor of Ras 1 |
| Protein Family: | Kinase suppressor of Ras |
| UniProt Gene Name: | KSR1 |
| UniProt Entry Name: | KSR1_HUMAN |
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