Epigenetics & Nuclear Signaling Antibodies 4
Anti-Phospho-JUNB-S259 Antibody (CABP0375)
- SKU:
- CABP0375
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-Phospho-JUNB-S259 Antibody |
| Antibody SKU: | CABP0375 |
| Antibody Size: | 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S259 of human JUNB |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, HT-29+EGF |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S259 of human JUNB |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3726 |
| Uniprot: | P17275 |
| Cellular Location: | Nucleus |
| Calculated MW: | 35kDa |
| Observed MW: | 45kDa |
 | Western blot analysis of extracts from HT29 cells, using Phospho-JUNB-S259 antibody (CABP0375). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. |
 | Immunohistochemistry of paraffin-embedded human breast carcinoma using Phospho-JUNB-S259 antibody (CABP0375). |
| Synonyms: | JUNB, AP-1 |
| Background: | Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'. |
| UniProt Protein Function: | JunB: Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'. Binds DNA as an homodimer or as an heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains). By growth factors. Belongs to the bZIP family. Jun subfamily. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Transcription factor; Oncoprotein Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: chromatin; nuclear chromatin; nucleoplasm; transcription factor complex Molecular Function:DNA binding; protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor binding Biological Process: cellular response to hormone stimulus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell cycle; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; response to cAMP; response to cytokine stimulus; response to drug; response to lipopolysaccharide; response to mechanical stimulus; response to radiation |
| UniProt Code: | P17275 |
| NCBI GenInfo Identifier: | 135304 |
| NCBI Gene ID: | 3726 |
| NCBI Accession: | P17275.1 |
| UniProt Secondary Accession: | P17275,Q96GH3, |
| UniProt Related Accession: | P17275 |
| Molecular Weight: | 35,879 Da |
| NCBI Full Name: | Transcription factor jun-B |
| NCBI Synonym Full Names: | JunB proto-oncogene, AP-1 transcription factor subunit |
| NCBI Official Symbol: | JUNB |
| NCBI Official Synonym Symbols: | AP-1 |
| NCBI Protein Information: | transcription factor jun-B |
| UniProt Protein Name: | Transcription factor jun-B |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | JUNB |
| UniProt Entry Name: | JUNB_HUMAN |
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