Cell Biology Antibodies 14

Anti-Phospho-JNK1-T183/Y185 + JNK2-T183/Y185 + JNK3-T221/Y223 Antibody (CABP1163)

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SKU:
CABP1163
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-Phospho-JNK1-T183/Y185 + JNK2-T183/Y185 + JNK3-T221/Y223 Antibody
Antibody SKU:CABP1163
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic phosphorylated peptide around T183 & Y185 of human JNK1/2/3 (NP_620637.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T
Immunogen:A synthetic phosphorylated peptide around T183 & Y185 of human JNK1/2/3 (NP_620637.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5599/5601/5602
Uniprot:P45983/P45984/P53779
Cellular Location:
Calculated MW:35kDa/44kDa/48kDa/27kDa/52kDa
Observed MW:46KDa
Anti-Phospho-JNK1-T183/Y185 + JNK2-T183/Y185 + JNK3-T221/Y223 Antibody (CABP1163)Western blot - Phospho-JNK1-T183/Y185 + JNK2-T183/Y185 + JNK3-T221/Y223 Rabbit pAb (CABP1163)
Synonyms:
Background:The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
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