Cell Biology Antibodies 16
Anti-Phospho-IRS1-S636 Antibody (CABP0225)
- SKU:
- CABP0225
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Phospho-IRS1-S636 Antibody |
| Antibody SKU: | CABP0225 |
| Antibody Size: | 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S636 of human IRS1 |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:3000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 3T3 |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S636 of human IRS1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3667 |
| Uniprot: | P35568 |
| Cellular Location: | |
| Calculated MW: | 131kDa |
| Observed MW: | 170kDa |
 | Western blot analysis of extracts from 3T3 cells, using Phospho-IRS1-S636 antibody (CABP0225). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. |
| Synonyms: | HIRS-1, IRS1 |
| Background: | This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. |
| UniProt Protein Function: | IRS1: an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2. Phosphorylated on ser/thr residues by kinases including JNK and IKK. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q36 Cellular Component: intracellular membrane-bound organelle; cytoplasm; plasma membrane; caveola; cytosol; nucleus Molecular Function:insulin-like growth factor receptor binding; protein binding; signal transducer activity; protein kinase C binding; phosphoinositide 3-kinase binding; SH2 domain binding; transmembrane receptor protein tyrosine kinase adaptor protein activity; insulin receptor binding Biological Process: response to peptide hormone stimulus; phosphoinositide 3-kinase cascade; nerve growth factor receptor signaling pathway; positive regulation of glycogen biosynthetic process; negative regulation of insulin receptor signaling pathway; glucose homeostasis; signal transduction; negative regulation of insulin secretion; response to insulin stimulus; positive regulation of glucose import; mammary gland development; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; protein kinase B signaling cascade; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of phosphoinositide 3-kinase activity; positive regulation of fatty acid beta-oxidation; cellular response to insulin stimulus; insulin-like growth factor receptor signaling pathway; regulation of gene expression; insulin receptor signaling pathway; innate immune response; positive regulation of insulin receptor signaling pathway; lipid catabolic process; positive regulation of cell migration Disease: Diabetes Mellitus, Noninsulin-dependent |
| NCBI Summary: | This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009] |
| UniProt Code: | P35568 |
| NCBI GenInfo Identifier: | 547738 |
| NCBI Gene ID: | 3667 |
| NCBI Accession: | P35568.1 |
| UniProt Related Accession: | P35568 |
| Molecular Weight: | |
| NCBI Full Name: | Insulin receptor substrate 1 |
| NCBI Synonym Full Names: | insulin receptor substrate 1 |
| NCBI Official Symbol: | IRS1 |
| NCBI Official Synonym Symbols: | HIRS-1 |
| NCBI Protein Information: | insulin receptor substrate 1; IRS-1 |
| UniProt Protein Name: | Insulin receptor substrate 1 |
| Protein Family: | Isoleucine--tRNA ligase |
| UniProt Gene Name: | IRS1 |
| UniProt Entry Name: | IRS1_HUMAN |
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