Anti-Phospho-IRS1-S636/639 Antibody (CABP0551)

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SKU:
CABP0551
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HIRS-1
Synonyms:
IRS1
Research Area:
Cell Biology

Description

Product Name:Phospho-IRS1-S636/639 Rabbit pAb
Product Code:CABP0551
Size:20uL, 50uL, 100uL
Synonyms:HIRS-1, IRS1
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic phosphorylated peptide around S636 & S639 of human IRS1 (NP_005535.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T
Immunogen:A synthetic phosphorylated peptide around S636 & S639 of human IRS1 (NP_005535.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSPK SV
Gene ID:3667
Uniprot:P35568
Calculated MW:131kDa
Observed MW:180KDa
UniProt Protein Function:IRS1: an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2. Phosphorylated on ser/thr residues by kinases including JNK and IKK.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q36

Cellular Component: intracellular membrane-bound organelle; cytoplasm; plasma membrane; caveola; cytosol; nucleus

Molecular Function:insulin-like growth factor receptor binding; protein binding; signal transducer activity; protein kinase C binding; phosphoinositide 3-kinase binding; SH2 domain binding; transmembrane receptor protein tyrosine kinase adaptor protein activity; insulin receptor binding

Biological Process: response to peptide hormone stimulus; phosphoinositide 3-kinase cascade; nerve growth factor receptor signaling pathway; positive regulation of glycogen biosynthetic process; negative regulation of insulin receptor signaling pathway; glucose homeostasis; signal transduction; negative regulation of insulin secretion; response to insulin stimulus; positive regulation of glucose import; mammary gland development; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; protein kinase B signaling cascade; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of phosphoinositide 3-kinase activity; positive regulation of fatty acid beta-oxidation; cellular response to insulin stimulus; insulin-like growth factor receptor signaling pathway; regulation of gene expression; insulin receptor signaling pathway; innate immune response; positive regulation of insulin receptor signaling pathway; lipid catabolic process; positive regulation of cell migration

Disease: Diabetes Mellitus, Noninsulin-dependent

NCBI Summary:This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
UniProt Code:P35568
NCBI GenInfo Identifier:547738
NCBI Gene ID:3667
NCBI Accession:P35568.1
UniProt Related Accession:P35568
Molecular Weight:
NCBI Full Name:Insulin receptor substrate 1
NCBI Synonym Full Names:insulin receptor substrate 1
NCBI Official Symbol:IRS1  
NCBI Official Synonym Symbols:HIRS-1  
NCBI Protein Information:insulin receptor substrate 1; IRS-1
UniProt Protein Name:Insulin receptor substrate 1
Protein Family:Isoleucine--tRNA ligase
UniProt Gene Name:IRS1  
UniProt Entry Name:IRS1_HUMAN
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